P-Glycoprotein 抗体 (Center)
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Quick Overview for P-Glycoprotein 抗体 (Center) (ABIN2794800)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 647-677, Center
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原理
- Rabbit Anti-Human P-Glycoprotein (ABCB1) (Center) Antibody
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免疫原
- This P-Glycoprotein (ABCB1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 647-677 amino acids from the Central region of human P-Glycoprotein (ABCB1).
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亚型
- Ig Fraction
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anti-P-Glycoprotein (AA 647-677) antibody
适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-P-Glycoprotein antibody适用: 人, Hamster WB, IHC, FACS, ICC 宿主: 小鼠 Monoclonal JSB-1 unconjugated
anti-P-Glycoprotein antibody适用: 人, Hamster WB, IHC, FACS 宿主: 小鼠 Monoclonal JSB-1 unconjugated
anti-P-Glycoprotein (AA 647-677) antibody适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western Blot
Recommended Dilutions
WB: 1:1000ABCB1 Antibody (L661) . -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 2.000 mg/mL
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C (short-term), -20°C (long-term)
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- P-Glycoprotein
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背景
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Target Description: The membrane-associated ABCB1 protein is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. ABCB1 is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
Gene Symbol: ABCB1
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分子量
- 141479 Da
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基因ID
- 5243
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UniProt
- P08183
抗原
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