VAV1 抗体 (Middle Region)
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Quick Overview for VAV1 抗体 (Middle Region) (ABIN2792554)
抗原
See all VAV1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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原理
- VAV1 Antibody - middle region
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序列
- RDRSELSLKE GDIIKILNKK GQQGWWRGEI YGRVGWFPAN YVEEDYSEYC
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交叉反应
- 牛, 犬, 人, 小鼠, 大鼠
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预测反应
- Cow: 92%, Dog: 92%, Horse: 92%, Human: 100%, Mouse: 92%, Pig: 92%, Rabbit: 90%, Rat: 92%
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产品特性
- This is a rabbit polyclonal antibody against VAV1. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human VAV1
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anti-Vav 1 Oncogene (VAV1) (AA 121-324) antibody
VAV1 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 2E11 unconjugated
anti-Vav 1 Oncogene (VAV1) (AA 565-795) antibodyVAV1 适用: 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Vav 1 Oncogene (VAV1) (AA 681-790) antibodyVAV1 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 9C1 unconjugated
anti-Vav 1 Oncogene (VAV1) (AA 681-790) antibodyVAV1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3A11 unconjugated
anti-Vav 1 Oncogene (VAV1) (pTyr174) antibodyVAV1 适用: 人, 大鼠, 小鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Vav 1 Oncogene (VAV1) (Center) antibodyVAV1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Vav 1 Oncogene (VAV1) (Tyr174) antibodyVAV1 适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Vav 1 Oncogene (VAV1) (AA 100-200) antibodyVAV1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Vav 1 Oncogene (VAV1) (N-Term) antibodyVAV1 适用: 人, 大鼠, 小鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Vav 1 Oncogene (VAV1) (Tyr174) antibodyVAV1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- prevent freeze-thaw cycles
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储存条件
- 4 °C,-20 °C
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储存方法
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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- VAV1 (Vav 1 Oncogene (VAV1))
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别名
- VAV1
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背景
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Background Information: This protein is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Gene Name: Vav 1 guanine nucleotide exchange factor
Alternative Symbols: VAV
Protein Name: Proto-oncogene vav
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分子量
- 98kDa
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基因ID
- 7409
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NCBI登录号
- NP_005419
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UniProt
- P15498
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途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, BCR Signaling
抗原
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