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VAV1 抗体 (Middle Region)

This anti-VAV1 antibody is a 兔多克隆 antibody detecting VAV1 in WB. Suitable for 人, 大鼠, 小鼠, 犬, 马, Cow, Pig 和兔.

WB Suggested Anti-VAV1 Antibody Titration: 0. (VAV1 抗体 (Middle Region))

1 image

产品编号 ABIN2792554

发货至: 中国

Quick Overview for VAV1 抗体 (Middle Region) (ABIN2792554)

抗原

See all VAV1 抗体

VAV1 (Vav 1 Oncogene (VAV1))

适用

人, 大鼠, 小鼠, 犬, 马, Cow, Pig, 兔

宿主

兔

克隆类型

多克隆

标记

46
3
2
2
2
2
2
2
1
1
1
1

This VAV1 antibody is un-conjugated

应用范围

45
31
16
7
6
6
4
3
1
1
1
1

Western Blotting (WB)

Discover our top product VAV1 Primary Antibody

抗原表位
13

13

7

4

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Middle Region

序列

RDRSELSLKE GDIIKILNKK GQQGWWRGEI YGRVGWFPAN YVEEDYSEYC

交叉反应

牛, 犬, 人, 小鼠, 大鼠

预测反应

Cow: 92%, Dog: 92%, Horse: 92%, Human: 100%, Mouse: 92%, Pig: 92%, Rabbit: 90%, Rat: 92%

产品特性

This is a rabbit polyclonal antibody against VAV1. It was validated on Western Blot using a cell lysate as a positive control.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide directed towards the middle region of human VAV1
anti-Vav 1 Oncogene (VAV1) (AA 121-324) antibody
VAV1 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 2E11 unconjugated

anti-Vav 1 Oncogene (VAV1) (AA 565-795) antibody
VAV1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Vav 1 Oncogene (VAV1) (pTyr174) antibody
VAV1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated

anti-Vav 1 Oncogene (VAV1) (N-Term) antibody
VAV1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated

anti-Vav 1 Oncogene (VAV1) (AA 681-790) antibody
VAV1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 9C1 unconjugated

anti-Vav 1 Oncogene (VAV1) (AA 681-790) antibody
VAV1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3A11 unconjugated

anti-Vav 1 Oncogene (VAV1) (Center) antibody
VAV1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Vav 1 Oncogene (VAV1) (Tyr174) antibody
VAV1 适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Vav 1 Oncogene (VAV1) (AA 100-200) antibody
VAV1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Vav 1 Oncogene (VAV1) (Tyr174) antibody
VAV1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

WB Suggested Anti-VAV1 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:62500
Positive Control: Human heart.
Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 845 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
抗原

VAV1 (Vav 1 Oncogene (VAV1))

别名

VAV1

背景

This protein is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: VAV
Protein Interaction Partner: UBC, CD28, ERBB3, ERBB2, EGFR, PTPN22, SPI1, PLCG1, Mbp, CD5, PDGFRB, NOTCH1, FGFR1, DOK1, TUBB, SH3BP2, CBLB, CBL, FYN, SYK, LCP2, CD19, SOCS1, KHDRBS1, LMNA, TUBA1A, PHAX, ZAP70, ZNF655, DOCK2, XRCC5, PAG1, RACGAP1, MERTK, BLNK, NEK3, AOC3, ARHGDIB, DNM
Protein Size: 845

分子量

98 kDa

基因ID

7409

NCBI登录号

NM_005428, NP_005419

UniProt

P15498

途径

TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, BCR Signaling

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