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MDM4-binding Protein 抗体 (N-Term)

Name: MDM4-binding Protein 抗体 (N-Term)
SKU: ABIN2792185
Availability: OutOfStock

Cited in 1 publication. This anti-MDM4-binding Protein antibody is a 兔多克隆 antibody detecting MDM4-binding Protein in WB. Suitable for 人, Cow, Pig, 兔, 犬和马.

Lanes: 1. (MDM4-binding Protein 抗体 (N-Term))

WB Suggested Anti-MDM4 Antibody Titration: 0. (MDM4-binding Protein 抗体 (N-Term))

2 images

(1 reference)

产品编号 ABIN2792185

发货至: 中国

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Quick Overview for MDM4-binding Protein 抗体 (N-Term) (ABIN2792185)

抗原

See all MDM4-binding Protein (MDM4) 抗体

MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))

适用

人, Cow, Pig, 兔, 犬, 马

宿主

兔

克隆类型

多克隆

标记

This MDM4-binding Protein antibody is un-conjugated

应用范围

Western Blotting (WB)

Discover our top product MDM4 Primary Antibody

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N-Term

序列

IPSQDQLKQS AEESSTSRKR TTEDDIPTLP TSEHKCIHSR EDEDLIENLA

预测反应

Cow: 80%, Dog: 93%, Horse: 93%, Human: 100%, Pig: 86%, Rabbit: 80%

产品特性

This is a rabbit polyclonal antibody against MDM4. It was validated on Western Blot using a cell lysate as a positive control.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide directed towards the N terminal region of human MDM4
anti-Mdm4-binding Protein (MDM4) (AA 1-490) antibody
MDM4 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-Mdm4-binding Protein (MDM4) antibody
MDM4 适用: 人 ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 2D10F4 unconjugated

anti-Mdm4-binding Protein (MDM4) antibody
MDM4 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 2D11 unconjugated

anti-Mdm4-binding Protein (MDM4) (AA 1-490) antibody
MDM4 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated

anti-Mdm4-binding Protein (MDM4) antibody
MDM4 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 3A6 unconjugated

anti-Mdm4-binding Protein (MDM4) (pSer367) antibody
MDM4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Mdm4-binding Protein (MDM4) (AA 130-179) antibody
MDM4 适用: 人, Cow, Pig, 兔 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Mdm4-binding Protein (MDM4) (AA 301-400) antibody
MDM4 适用: 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Mdm4-binding Protein (MDM4) (AA 208-306) antibody
MDM4 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Mdm4-binding Protein (MDM4) (AA 381-490) antibody
MDM4 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 490 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Schlaeger, Longerich, Schiller, Bewerunge, Mehrabi, Toedt, Kleeff, Ehemann, Eils, Lichter, Schirmacher, Radlwimmer: "Etiology-dependent molecular mechanisms in human hepatocarcinogenesis." in: Hepatology (Baltimore, Md.), Vol. 47, Issue 2, pp. 511-20, (2008) (PubMed).
抗原

MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))

别名

MDM4

背景

MDM4 inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. It inhibits degradation of MDM2. It can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation and apoptotic functions. The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: DKFZp781B1423, MDMX, MGC132766, MRP1, HDMX
Protein Interaction Partner: RNF115, CAPN7, CD160, MDM2, TP53, UBC, MDM4, USP2, YWHAG, UBE2D2, PRKAA1, BCL2, RPS20, RPS15, RPL37, YWHAQ, HSP90AA1, CSNK1A1, PPP1CC, PPP1CB, PPP1CA, RB1, APP, UBE2D3, UBE2D1, MNAT1, ABL1, LRSAM1, TRIM55, TRIM46, MKRN3, YWHAZ, YWHAE, YWHAB, CDKN1A, RFWD2
Protein Size: 490

分子量

55 kDa

基因ID

4194

NCBI登录号

NM_002393, NP_002384

UniProt

O15151

途径

Cell Division Cycle