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MACROD1 抗体 (N-Term)

This 兔 多克隆 anti-MACROD1 antibody specifically detects MACROD1 in WB. The antibody is reactive with 人, Cow, 犬, 豚鼠, 马, 小鼠 和 大鼠 samples.
产品编号 ABIN2791083
发货至: 中国
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Quick Overview for MACROD1 抗体 (N-Term) (ABIN2791083)

抗原

MACROD1 (MACRO Domain Containing 1 (MACROD1))

适用

人, Cow, 犬, 豚鼠, 马, 小鼠, 大鼠

宿主

  • 6

克隆类型

  • 6
多克隆

标记

  • 2
  • 2
  • 1
  • 1
This MACROD1 antibody is un-conjugated

应用范围

  • 4
  • 1
  • 1
Western Blotting (WB)
  • 抗原表位

    • 5
    • 1
    N-Term

    序列

    MAAKVDLSTS TDWKEAKSFL KGLSDKQREE HYFCKDFVRL KKIPTWKEMA

    预测反应

    Cow: 100%, Dog: 92%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%

    产品特性

    This is a rabbit polyclonal antibody against MACROD1. It was validated on Western Blot.

    纯化方法

    Affinity Purified

    免疫原

    The immunogen is a synthetic peptide directed towards the N-terminal region of Human MACROD1
  • 应用备注

    Optimal working dilutions should be determined experimentally by the investigator.

    说明

    Antigen size: 325 AA

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    Lot specific

    缓冲液

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze-thaw cycles.

    储存条件

    -20 °C

    储存方法

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原

    MACROD1 (MACRO Domain Containing 1 (MACROD1))

    别名

    MACROD1

    背景

    MACROD1 deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. It plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen and may play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. It could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction and could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. MACROD1 enhances ESR1-mediated transcription activity.
    Alias Symbols: LRP16
    Protein Interaction Partner: BAG3, EPB41,
    Protein Size: 325

    分子量

    36 kDa

    基因ID

    28992

    NCBI登录号

    NM_014067, NP_054786

    UniProt

    Q9BQ69
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