WISP2 抗体 (C-Term)
Quick Overview for WISP2 抗体 (C-Term) (ABIN2789751)
抗原
See all WISP2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- WGPCSTTCGL GMATRVSNQN RFCRLETQRR LCLSRPCPPS RGRSPQNSAF
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预测反应
- Dog: 79%, Horse: 79%, Human: 100%, Pig: 79%, Rat: 79%
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产品特性
- This is a rabbit polyclonal antibody against WISP2. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 250 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- WISP2 (WNT1 Inducible Signaling Pathway Protein 2 (WISP2))
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别名
- WISP2
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背景
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This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72 % identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.
Alias Symbols: CCN5, CT58, CTGF-L
Protein Interaction Partner: HDAC3, HDAC1, IGF1R, IGF2R,
Protein Size: 250 -
分子量
- 24 kDa
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基因ID
- 8839
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NCBI登录号
- NM_003881, NP_003872
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UniProt
- O76076
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途径
- WNT signaling, Growth Factor Binding
抗原
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