PLAU 抗体 (C-Term)
Quick Overview for PLAU 抗体 (C-Term) (ABIN2789605)
抗原
See all PLAU 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
 - C-Term
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序列
 - CSLQGRMTLT GIVSWGRGCA LKDKPGVYTR VSHFLPWIRS HTKEENGLAL
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预测反应
 - Horse: 86%, Human: 100%, Rabbit: 86%, Yeast: 100%
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产品特性
 - This is a rabbit polyclonal antibody against PLAU. It was validated on Western Blot.
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纯化方法
 - Affinity Purified
 
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应用备注
 - Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 431 AA
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限制
 - 仅限研究用
 
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状态
 - Liquid
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浓度
 - Lot specific
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缓冲液
 - Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
 - Sodium azide
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注意事项
 - This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
 - Avoid repeated freeze-thaw cycles.
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储存条件
 - -20 °C
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储存方法
 - For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
 
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- PLAU (Plasminogen Activator, Urokinase (PLAU))
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别名
 - PLAU
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背景
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                        This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.
Alias Symbols: ATF, UPA, URK, u-PA, QPD, BDPLT5
Protein Interaction Partner: TEX101, UBC, PLAUR, SUMO1, NEDD8, CEBPG, ELAVL1, MYC, BTK, ALAS1, SCAMP5, PDGFC, ST14, SERPINA5, LRP2, SERPINF2, F2, SERPINB2, PLAT, SERPINE1, PLG, SERPINB6, IGF2R, HGF, NID1, CTSL, CTSB, MAP2K1, HRAS, SERPINE2,
Protein Size: 431 - 
                                            
分子量
 - 28 kDa
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基因ID
 - 5328
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NCBI登录号
 - NM_002658, NP_002649
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UniProt
 - P00749
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途径
 - Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration
 
抗原
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