MC1 Receptor 抗体 (C-Term)
Quick Overview for MC1 Receptor 抗体 (C-Term) (ABIN2789427)
抗原
See all MC1 Receptor (MC1R) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- CPEHPTCGCI FKNFNLFLAL IICNAIIDPL IYAFHSQELR RTLKEVLTCS
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预测反应
- Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 93%, Rat: 93%
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产品特性
- This is a rabbit polyclonal antibody against MC1R. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the C-terminal region of MC1R
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anti-Melanocortin 1 Receptor (MC1R) (AA 1-37) antibody
MC1R 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Melanocortin 1 Receptor (MC1R) (AA 271-317) antibodyMC1R 适用: 人, 小鼠 ELISA, WB, IF (cc), IF (p), FACS, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Melanocortin 1 Receptor (MC1R) (C-Term) antibodyMC1R 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Melanocortin 1 Receptor (MC1R) (C-Term) antibodyMC1R 适用: 人 WB, IF, IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Melanocortin 1 Receptor (MC1R) (AA 217-232) antibodyKO Validated MC1R 适用: 人 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Melanocortin 1 Receptor (MC1R) (Cytoplasmic Domain) antibodyMC1R 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Melanocortin 1 Receptor (MC1R) antibodyMC1R 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Melanocortin 1 Receptor (MC1R) (AA 271-317) antibody (AbBy Fluor® 488)MC1R 适用: 人, 小鼠 WB, IF (cc), IF (p), FACS 宿主: 兔 Polyclonal AbBy Fluor® 488
anti-Melanocortin 1 Receptor (MC1R) (C-Term) antibodyMC1R 适用: 人 ELISA, WB, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 317 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))
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别名
- MC1R
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背景
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This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.
Alias Symbols: CMM5, MGC14337, MSH-R, SHEP2
Protein Interaction Partner: SUMO2, RIC8A, OGFOD1, TRNT1, EZR, UBA1, PYGL, AHCY, UBC, MGRN1, ASIP, POMC, MC4R,
Protein Size: 317 -
分子量
- 35 kDa
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基因ID
- 4157
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NCBI登录号
- NM_002386, NP_002377
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UniProt
- Q01726
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途径
- cAMP Metabolic Process, Feeding Behaviour
抗原
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