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Complement Factor I 抗体 (N-Term)

This anti-Complement Factor I antibody is a 兔 多克隆 antibody detecting Complement Factor I in WB. Suitable for 人.
产品编号 ABIN2789418
发货至: 中国

Quick Overview for Complement Factor I 抗体 (N-Term) (ABIN2789418)

抗原

See all Complement Factor I (CFI) 抗体
Complement Factor I (CFI)

适用

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宿主

  • 36
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克隆类型

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多克隆

标记

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This Complement Factor I antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 抗原表位

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    N-Term

    序列

    WSMREANVAC LDLGFQQGAD TQRRFKLSDL SINSTECLHV HCRGLETSLA

    预测反应

    Human: 100%

    产品特性

    This is a rabbit polyclonal antibody against CFI. It was validated on Western Blot.

    纯化方法

    Affinity Purified
  • 应用备注

    Optimal working dilutions should be determined experimentally by the investigator.

    说明

    Antigen size: 583 AA

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    Lot specific

    缓冲液

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze-thaw cycles.

    储存条件

    -20 °C

    储存方法

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原

    Complement Factor I (CFI)

    别名

    CFI

    背景

    This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene.
    Alias Symbols: AHUS3, C3BINA, C3b-INA, FI, IF, KAF
    Protein Interaction Partner: GLP1R, CFH, C3,
    Protein Size: 583

    分子量

    64 kDa

    基因ID

    3426

    NCBI登录号

    NM_000204, NP_000195

    UniProt

    P05156

    途径

    Complement System
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