CD33 抗体 (N-Term)
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北京 101111
Quick Overview for CD33 抗体 (N-Term) (ABIN2789356)
抗原
See all CD33 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- CD33 Antibody - N-terminal region
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序列
- HPIPYYDKNS PVHGYWFREG AIISRDSPVA TNKLDQEVQE ETQGRFRLLG
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预测反应
- Cow: 79%, Horse: 79%, Human: 100%
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产品特性
- This is a rabbit polyclonal antibody against CD33. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63067-100UG
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- prevent freeze-thaw cycles
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储存条件
- 4 °C,-20 °C
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储存方法
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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- CD33
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别名
- CD33
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背景
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Background Information: CD33 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. CD33 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, CD33 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 induces apoptosis in acute myeloid leukemia (in vitro).
Gene Name: CD33 Molecule
Alternative Symbols: p67, SIGLEC3, SIGLEC-3
Protein Name: Myeloid cell surface antigen CD33
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分子量
- 38kDa
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基因ID
- 945
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NCBI登录号
- NP_001763
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UniProt
- P20138
抗原
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