WWOX 抗体 (C-Term)
Quick Overview for WWOX 抗体 (C-Term) (ABIN2788787)
抗原
See all WWOX 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- DDNPTKPTTR QRYDGSTTAM EILQGRDFTG KVVVVTGANS GIGFETAKSF
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预测反应
- Cow: 100%, Dog: 92%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 93%, Rat: 100%
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产品特性
- This is a rabbit polyclonal antibody against WWOX. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 189 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- WWOX (WW Domain Containing Oxidoreductase (WWOX))
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别名
- WWOX
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背景
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WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90 % identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.
Alias Symbols: D16S432E, FOR, FRA16D, HHCMA56, PRO0128, SDR41C1, WOX1
Protein Interaction Partner: ITCH, TRIM28, HUWE1, UBC, ATM, RPRD2, CYFIP1, SPG20, SNRNP200, ACIN1, SLC4A1AP, DHX30, SCAF8, XRN2, GABARAPL2, SEC23IP, HNRNPUL1, DIDO1, CPSF6, SF3B2, SF3A3, SRSF10, USP39, IGF2BP2, IGF2BP3, IGF2BP1, PAICS, PRPF8, CCT2, CCT7, NOP56, DDX17, SEC23A, BAIAP2,
Protein Size: 189 -
分子量
- 21 kDa
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基因ID
- 51741
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NCBI登录号
- NM_130791, NP_570607
抗原
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