SH2D1A 抗体 (C-Term)
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北京 101111
Quick Overview for SH2D1A 抗体 (C-Term) (ABIN2788421)
抗原
See all SH2D1A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- YFRKIKNLIS AFQKPDQGIV IPLQYPVEKK SSARSTQGTT GIREDPDVCL
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预测反应
- Cow: 86%, Horse: 92%, Human: 100%, Pig: 100%, Rat: 93%
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产品特性
- This is a rabbit polyclonal antibody against SH2D1A. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the C terminal region of human SH2D1A
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anti-SH2 Domain Containing 1A (SH2D1A) (AA 1-128) antibody
SH2D1A 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1C9 unconjugated
anti-SH2 Domain Containing 1A (SH2D1A) (AA 1-128) antibodySH2D1A 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-SH2 Domain Containing 1A (SH2D1A) (AA 11-124) antibodySH2D1A 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SH2 Domain Containing 1A (SH2D1A) (C-Term) antibodySH2D1A 适用: 人, 猴, 兔, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-SH2 Domain Containing 1A (SH2D1A) (AA 18-115) antibodySH2D1A 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-SH2 Domain Containing 1A (SH2D1A) (Internal Region) antibodyVerified SH2D1A 适用: 人 WB, ELISA, IP 宿主: 山羊 Polyclonal unconjugated
anti-SH2 Domain Containing 1A (SH2D1A) (AA 1-128) antibodySH2D1A 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-SH2 Domain Containing 1A (SH2D1A) (AA 85-114), (C-Term) antibodySH2D1A 适用: 人 WB 宿主: 兔 Polyclonal RB41923 unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 128 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- SH2D1A (SH2 Domain Containing 1A (SH2D1A))
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别名
- SH2D1A
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背景
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SH2D1A is a protein that plays a major role in the bidirectional stimulation of T and B cells. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in SH2D1A gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma.
Alias Symbols: DSHP, EBVS, FLJ18687, FLJ92177, IMD5, LYP, MTCP1, SAP, XLP, XLPD, SAP/SH2D1A
Protein Interaction Partner: LHX4, TNK2, UBC, LYN, MAPK11, MAPK1, ERBB3, EGFR, MAPK14, CD244, ELAVL1, SLAMF7, SLAMF6, ARHGEF7, CD84, SLAMF1, DOK1, FYB, LY9, ARHGEF6, LCK, FYN, GRB2,
Protein Size: 128 -
分子量
- 14 kDa
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基因ID
- 4068
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NCBI登录号
- NM_002351, NP_002342
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UniProt
- O60880
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
抗原
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