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FGFR2 抗体 (C-Term)

This anti-FGFR2 antibody is a 兔 多克隆 antibody detecting FGFR2 in WB. Suitable for 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼 和 绵羊.
产品编号 ABIN2788319
发货至: 中国

Quick Overview for FGFR2 抗体 (C-Term) (ABIN2788319)

抗原

See all FGFR2 抗体
FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))

适用

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人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼, 绵羊

宿主

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克隆类型

  • 103
  • 28
多克隆

标记

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This FGFR2 antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 抗原表位

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    C-Term

    序列

    KPKEAVTVAV KMLKDDATEK DLSDLVSEME MMKMIGKHKN IINLLGACTQ

    预测反应

    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 93%, Zebrafish: 100%

    产品特性

    This is a rabbit polyclonal antibody against FGFR2. It was validated on Western Blot.

    纯化方法

    Affinity Purified

    免疫原

    The immunogen is a synthetic peptide directed towards the C terminal region of human FGFR2
  • 应用备注

    Optimal working dilutions should be determined experimentally by the investigator.

    说明

    Antigen size: 705 AA

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    Lot specific

    缓冲液

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze-thaw cycles.

    储存条件

    -20 °C

    储存方法

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原

    FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))

    别名

    FGFR2

    背景

    The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
    Alias Symbols: BEK, BFR-1, CD332, CEK3, CFD1, ECT1, FLJ98662, JWS, K-SAM, KGFR, TK14, TK25
    Protein Interaction Partner: PPM1A, APP, HGS, UBC, LYN, FYN, CBL, NEDD4, FRS2, STAT5B, STAT5A, PGR, STAT3, ITGA5, PAK4, FGF23, FGF18, FGF17, EPHA4, FGF10, PTK2B, FGF9, FGF8, PLCG1, FGF5, FGF4, FGF3, FGF7, FGF6, FGF1, CACNA1D, PIK3R1, FGFR2,
    Protein Size: 705

    分子量

    78 kDa

    基因ID

    2263

    NCBI登录号

    NM_022970, NP_075259

    UniProt

    P21802

    途径

    RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Growth Factor Binding
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