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- 抗原 See all AP2A2 抗体
- AP2A2 (Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2))
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抗原表位
- C-Term
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适用
- 人, 小鼠, 大鼠, 犬, 豚鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This AP2A2 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- LAKLKKKKGP STVTDLEDTK RDRSVDVNGG PEPAPASTSA VSTPSPSADL
- 预测反应
- Dog: 79%, Guinea Pig: 79%, Human: 100%, Mouse: 79%, Rat: 79%
- 产品特性
- This is a rabbit polyclonal antibody against AP2A2. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the C terminal region of human AP2A2
- Top Product
- Discover our top product AP2A2 Primary Antibody
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anti-Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2) (AA 590-939) antibody
AP2A2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2) (AA 590-939) antibodyAP2A2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2) (AA 21-150) antibodyAP2A2 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2) (Internal Region) antibodyAP2A2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2) (AA 610-637) antibodyAP2A2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB22030 unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2) antibodyAP2A2 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2) (AA 612-661) antibodyAP2A2 适用: 人, 小鼠, 大鼠, 犬, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2) (C-Term) antibodyAP2A2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 939 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- AP2A2 (Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2))
- 别名
- AP2A2 (AP2A2 产品)
- 背景
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AP2A2 is a component of the adaptor protein complex 2 (AP-2). AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif .
Alias Symbols: ADTAB, CLAPA2, HIP9, HYPJ, HIP-9
Protein Interaction Partner: PIP5K1C, UBC, ATP1A1, SUMO2, EGFR, RPA3, RPA2, RPA1, BIN1, PPP6R3, PAN2, SMAD1, FN1, DAB2, VCP, APP, AP2A1, SHC1, GRK5, EPS15, AP2M1, CLTC, GRB2, ARRB2, Rnf111, TERF2, DNAJC6, SNAP91, EPN1, AP2A2, NUMB, AP1S1, DNM1, AP2B1, AMPH, HTT, ATR, ATM, RALBP1,
Protein Size: 939 - 分子量
- 104 kDa
- 基因ID
- 161
- NCBI登录号
- NM_012305, NP_036437
- UniProt
- O94973
- 途径
- EGFR Signaling Pathway, Neurotrophin Signaling Pathway, EGFR Downregulation, SARS-CoV-2 Protein Interactome
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