USP8 抗体 (C-Term)
Quick Overview for USP8 抗体 (C-Term) (ABIN2788008)
抗原
See all USP8 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- FAGYSQQDSQ ELLLFLMDGL HEDLNKADNR KRYKEENNDH LDDFKAAEHA
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预测反应
- Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 93%, Rat: 93%, Zebrafish: 79%
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产品特性
- This is a rabbit polyclonal antibody against USP8. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the C terminal region of human USP8
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anti-Ubiquitin Specific Peptidase 8 (USP8) antibody
USP8 适用: 人 WB, IF, IP, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 8 (USP8) (AA 1-270), (C-Term) antibodyUSP8 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 8 (USP8) (AA 1-270) antibodyUSP8 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 8 (USP8) (AA 861-910) antibodyUSP8 适用: 人, 小鸡, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 8 (USP8) (AA 151-200) antibodyUSP8 适用: 人, Pig, Cow, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 8 (USP8) (AA 777-1118) antibodyUSP8 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 8 (USP8) (AA 1058-1087), (C-Term) antibodyUSP8 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB04288 unconjugated
anti-Ubiquitin Specific Peptidase 8 (USP8) (C-Term) antibodyUSP8 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 1118 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- USP8 (Ubiquitin Specific Peptidase 8 (USP8))
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别名
- USP8
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背景
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USP8 is a hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. USP8 converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. USP8 catalytic activity is enhanced in the M phase. USP8 is involved in cell proliferation. USP8 is required to enter into S phase in response to serum stimulation. USP8 may regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. USP8 probably regulates the stability of STAM2 and RASGRF1. USP8 regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle.USP8 deubiquitinates EPS15 and controles tyrosine kinase stability.USP8 removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. USP8 is involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules.
Alias Symbols: FLJ34456, HumORF8, KIAA0055, MGC129718, UBPY
Protein Interaction Partner: VAMP8, LRIG1, TARDBP, UBC, PTEN, STAT6, TSEN2, POLD3, HTT, YWHAB, YWHAQ, YWHAE, EGFR, PTPN23, SRC, ERBB4, UBE2I, UBE2G1, FARSB, VPS4B, TRIM63, TRIM55, PJA1, USP28, TRIM54, USP21, USP15, GRAP2, CHMP4C, CHMP1B, CHMP2A, CHMP2B, RNF41, USP8, SPP1, CHMP1A, NBR
Protein Size: 1118 -
分子量
- 127 kDa
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基因ID
- 9101
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NCBI登录号
- NM_005154, NP_005145
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UniProt
- P40818
抗原
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