Rubicon 抗体 (Middle Region)
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北京 101111
Quick Overview for Rubicon 抗体 (Middle Region) (ABIN2787888)
抗原
See all Rubicon (KIAA0226) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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原理
- RUBCN Antibody - middle region
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序列
- DQEGGGESQL SSVLRRSSFS EGQTLTVTSG AKKSHIRSHS DTSIASRGAP
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预测反应
- Cow: 85%, Dog: 85%, Guinea Pig: 92%, Human: 100%, Mouse: 92%, Rabbit: 85%, Rat: 100%
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产品特性
- This is a rabbit polyclonal antibody against KIAA0226. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human KIAA0226
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP58950-100UG
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- prevent freeze-thaw cycles
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储存条件
- 4 °C,-20 °C
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储存方法
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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- Rubicon (KIAA0226) (KIAA0226)
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别名
- RUBCN
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背景
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Background Information: The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Gene Name: RUN and cysteine rich domain containing beclin 1 interacting protein
Alternative Symbols: SCAR15, RUBICON, KIAA0226
Protein Name: run domain Beclin-1-interacting and cysteine-rich domain-containing protein
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分子量
- 103kDa
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基因ID
- 9711
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NCBI登录号
- NP_001139114
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UniProt
- Q92622
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途径
- Autophagy
抗原
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