NOG 抗体 (Middle Region)
Quick Overview for NOG 抗体 (Middle Region) (ABIN2787823)
抗原
See all NOG 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- GGHYDPGFMA TSPPEDRPGG GGGAAGGAED LAELDQLLRQ RPSGAMPSEI
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预测反应
- Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Sheep: 100%
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产品特性
- This is a rabbit polyclonal antibody against NOG. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human NOG
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anti-Noggin (NOG) (AA 28-232) antibody
NOG 适用: 人, 犬 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 4C12 unconjugated
anti-Noggin (NOG) (AA 28-232) antibodyNOG 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal A7 unconjugated
anti-Noggin (NOG) (AA 28-232) antibodyNOG 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Noggin (NOG) (AA 1-232) antibodyNOG 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Noggin (NOG) (AA 28-130) antibodyNOG 适用: 小鼠, 大鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Noggin (NOG) (AA 28-232) antibodyNOG 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Noggin (NOG) antibodyNOG 适用: 人, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Noggin (NOG) (AA 21-70) antibodyNOG 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Noggin (NOG) (AA 28-232) antibodyNOG 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4C9 unconjugated
anti-Noggin (NOG) (AA 1-232) antibodyNOG 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 232 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- NOG (Noggin (NOG))
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别名
- NOG
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背景
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The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified, both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse.
Alias Symbols: SYM1, SYNS1
Protein Interaction Partner: BMP7, BMP5, BMP4, BMP2, NOG,
Protein Size: 232 -
分子量
- 24 kDa
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基因ID
- 9241
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NCBI登录号
- NM_005450, NP_005441
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UniProt
- Q13253
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途径
- Stem Cell Maintenance, Tube Formation
抗原
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