C11orf73 抗体 (Middle Region)
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北京 101111
Quick Overview for C11orf73 抗体 (Middle Region) (ABIN2786966)
抗原
See all C11orf73 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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原理
- HIKESHI Antibody - middle region
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序列
- DNFYNFASSF AVSQAQMTPS PSEMFIPANV VLKWYENFQR RLAQNPLFWK
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 90%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Yeast: 90%, Zebrafish: 86%
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产品特性
- This is a rabbit polyclonal antibody against C11orf73. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human C11orf73
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anti-Chromosome 11 Open Reading Frame 73 (C11orf73) (AA 6-35), (N-Term) antibody
C11orf73 适用: 人, Hamster WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB28622 unconjugated
anti-Chromosome 11 Open Reading Frame 73 (C11orf73) (AA 9-39), (N-Term) antibodyC11orf73 适用: 人, Hamster WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 11 Open Reading Frame 73 (C11orf73) (AA 1-197) antibodyC11orf73 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 11 Open Reading Frame 73 (C11orf73) (C-Term) antibodyC11orf73 适用: 人, Hamster, 小鼠, 大鼠, 马, Cow, 犬, Pig, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 11 Open Reading Frame 73 (C11orf73) (AA 37-86) antibodyC11orf73 适用: 人, 小鼠, 大鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP56903-100UG
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- prevent freeze-thaw cycles
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储存条件
- 4 °C,-20 °C
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储存方法
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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- C11orf73 (Chromosome 11 Open Reading Frame 73 (C11orf73))
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别名
- HIKESHI
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背景
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Background Information: This gene encodes an evolutionarily conserved nuclear transport receptor that mediates heat-shock-induced nuclear import of 70 kDa heat-shock proteins (Hsp70s) through interactions with FG-nucleoporins. The protein mediates transport of the ATP form but not the ADP form of Hsp70 proteins under conditions of heat shock stress. Structural analyses demonstrate that the protein forms an asymmetric homodimer and that the N-terminal domain consists of a jelly-roll/beta-sandwich fold structure that contains hydrophobic pockets involved in FG-nucleoporin recognition. Reduction of RNA expression levels in HeLa cells using small interfering RNAs results in inhibition of heat shock-induced nuclear accumulation of Hsp70s, indicating a role for this gene in regulation of Hsp70 nuclear import during heat shock stress.
Gene Name: Hikeshi, heat shock protein nuclear import factor
Alternative Symbols: HLD13, L7RN6, OPI10, HSPC138, HSPC179, C11orf73
Protein Name: protein Hikeshi
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分子量
- 21kDa
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基因ID
- 51501
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NCBI登录号
- NP_057485
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UniProt
- Q53FT3
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途径
- Protein targeting to Nucleus
抗原
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