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PDE4B 抗体 (Middle Region)

PDE4B 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, Pig, 兔 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2786603
发货至: 中国
  • 抗原 See all PDE4B 抗体
    PDE4B (phosphodiesterase 4B, cAMP-Specific (PDE4B))
    抗原表位
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    适用
    • 36
    • 12
    • 11
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, Pig, 兔
    宿主
    • 35
    • 2
    • 1
    克隆类型
    • 36
    • 2
    多克隆
    标记
    • 20
    • 6
    • 5
    • 3
    • 2
    • 2
    This PDE4B antibody is un-conjugated
    应用范围
    • 32
    • 23
    • 14
    • 12
    • 9
    • 8
    • 8
    • 6
    • 2
    • 1
    • 1
    Western Blotting (WB)
    序列
    QDILDTLEDN RNWYQSMIPQ SPSPPLDEQN RDCQGLMEKF QFELTLDEED
    预测反应
    Cow: 100%, Dog: 100%, Guinea Pig: 83%, Horse: 100%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 93%, Rat: 93%
    产品特性
    This is a rabbit polyclonal antibody against PDE4B. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the middle region of human PDE4B
    Top Product
    Discover our top product PDE4B Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 564 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Fatemi, King, Reutiman, Folsom, Laurence, Lee, Fan, Paciga, Conti, Menniti: "PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia." in: Schizophrenia research, Vol. 101, Issue 1-3, pp. 36-49, (2008) (PubMed).

  • 抗原
    PDE4B (phosphodiesterase 4B, cAMP-Specific (PDE4B))
    别名
    PDE4B (PDE4B 产品)
    别名
    dpde4 antibody, pde4b5 antibody, pdeivb antibody, Dpde4 antibody, R74983 antibody, dunce antibody, PDE4/IVb antibody, Pde4B1 antibody, Pde4B2 antibody, Pde4B3 antibody, Pde4B4 antibody, DPDE4 antibody, PDE4B5 antibody, PDEIVB antibody, phosphodiesterase 4B antibody, phosphodiesterase 4B, cAMP specific antibody, phosphodiesterase 4B S homeolog antibody, pde4b antibody, PDE4B antibody, Pde4b antibody, pde4b.S antibody
    背景
    The specific function of this protein remains unknown.This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
    Alias Symbols: DKFZp686F2182, DPDE4, MGC126529, PDE4B5, PDEIVB
    Protein Interaction Partner: MAGEA11, RCBTB2, APOA1, ALB, PAFAH1B1, UBC, DISC1, PRKACA,
    Protein Size: 564
    分子量
    64 kDa
    基因ID
    5142
    NCBI登录号
    NM_001037339, NP_001032416
    UniProt
    Q5TEK5
    途径
    Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Myometrial Relaxation and Contraction
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