PDE4B 抗体 (Middle Region)
(1 reference)Quick Overview for PDE4B 抗体 (Middle Region) (ABIN2786603)
抗原
See all PDE4B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- QDILDTLEDN RNWYQSMIPQ SPSPPLDEQN RDCQGLMEKF QFELTLDEED
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 83%, Horse: 100%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 93%, Rat: 93%
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产品特性
- This is a rabbit polyclonal antibody against PDE4B. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human PDE4B
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anti-phosphodiesterase 4B, cAMP-Specific (PDE4B) (AA 500-736) antibody
PDE4B 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-phosphodiesterase 4B, cAMP-Specific (PDE4B) (C-Term) antibodyVerified PDE4B 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-phosphodiesterase 4B, cAMP-Specific (PDE4B) (AA 27-215) antibodyPDE4B 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-phosphodiesterase 4B, cAMP-Specific (PDE4B) (C-Term) antibodyPDE4B 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-phosphodiesterase 4B, cAMP-Specific (PDE4B) (AA 467-516) antibodyPDE4B 适用: 人, 大鼠, Cow, 犬, 豚鼠, 马, Pig, Bat, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-phosphodiesterase 4B, cAMP-Specific (PDE4B) antibodyPDE4B 适用: 人, 小鼠 WB, IHC, FACS, IF, IHC (p) 宿主: 小鼠 Monoclonal 1D12 unconjugated
anti-phosphodiesterase 4B, cAMP-Specific (PDE4B) (AA 62-111) antibodyPDE4B 适用: 人, 大鼠, 小鼠, Cow, 犬, 豚鼠, 马, Pig, Bat, 猴, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-phosphodiesterase 4B, cAMP-Specific (PDE4B) antibodyPDE4B 适用: 人 ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-phosphodiesterase 4B, cAMP-Specific (PDE4B) (N-Term) antibodyPDE4B 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-phosphodiesterase 4B, cAMP-Specific (PDE4B) (AA 189-217) antibodyPDE4B 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB18545 unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 564 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia." in: Schizophrenia research, Vol. 101, Issue 1-3, pp. 36-49, (2008) (PubMed).
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: "PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia." in: Schizophrenia research, Vol. 101, Issue 1-3, pp. 36-49, (2008) (PubMed).
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- PDE4B (phosphodiesterase 4B, cAMP-Specific (PDE4B))
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别名
- PDE4B
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背景
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The specific function of this protein remains unknown.This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Alias Symbols: DKFZp686F2182, DPDE4, MGC126529, PDE4B5, PDEIVB
Protein Interaction Partner: MAGEA11, RCBTB2, APOA1, ALB, PAFAH1B1, UBC, DISC1, PRKACA,
Protein Size: 564 -
分子量
- 64 kDa
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基因ID
- 5142
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NCBI登录号
- NM_001037339, NP_001032416
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UniProt
- Q5TEK5
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途径
- Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Myometrial Relaxation and Contraction
抗原
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