Norrie Disease (Pseudoglioma) 抗体 (Middle Region)
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Quick Overview for Norrie Disease (Pseudoglioma) 抗体 (Middle Region) (ABIN2786504)
抗原
See all Norrie Disease (Pseudoglioma) (NDP) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- DPRRCMRHHY VDSISHPLYK CSSKMVLLAR CEGHCSQASR SEPLVSFSTV
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
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产品特性
- This is a rabbit polyclonal antibody against NDP. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human NDP
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anti-Norrie Disease (Pseudoglioma) (NDP) (AA 25-133) antibody
NDP 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Norrie Disease (Pseudoglioma) (NDP) antibodyNDP 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Norrie Disease (Pseudoglioma) (NDP) (AA 25-133) antibodyNDP 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Norrie Disease (Pseudoglioma) (NDP) (AA 1-133) antibodyNDP 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Norrie Disease (Pseudoglioma) (NDP) antibodyNDP 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Norrie Disease (Pseudoglioma) (NDP) (N-Term) antibodyNDP 适用: 人 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 133 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Norrie Disease (Pseudoglioma) (NDP)
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别名
- NDP
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背景
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NDP activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. NDP plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. NDP acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). NDP may be involved in a pathway that regulates neural cell differentiation and proliferation. NDP is the genetic locus identified as harboring mutations that result in Norrie disease. Norrie disease is a rare genetic disorder characterized by bilateral congenital blindness that is caused by a vascularized mass behind each lens due to a maldeveloped retina (pseudoglioma). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-94 AL034370.1 53727-53820 c 95-1761 X65882.1 1-1667 1762-1935 BE139596.1 1-174 c
Alias Symbols: EVR2, FEVR, ND
Protein Interaction Partner: FZD4, NDP, BAG3, APP, LGALS8, PPP1CA,
Protein Size: 133 -
分子量
- 15 kDa
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基因ID
- 4693
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NCBI登录号
- NM_000266, NP_000257
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UniProt
- Q00604
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途径
- Sensory Perception of Sound
抗原
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