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Norrie Disease (Pseudoglioma) 抗体

NDP 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6263552
发货至: 中国
  • 抗原 See all Norrie Disease (Pseudoglioma) (NDP) 抗体
    Norrie Disease (Pseudoglioma) (NDP)
    适用
    • 33
    • 11
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 31
    • 3
    克隆类型
    • 33
    • 1
    多克隆
    标记
    • 12
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    This Norrie Disease (Pseudoglioma) antibody is un-conjugated
    应用范围
    • 10
    • 8
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    特异性
    NDP Antibody detects endogenous levels of total NDP
    交叉反应
    人, 小鼠, 大鼠
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human NDP
    亚型
    IgG
  • 应用备注
    WB 1:500-1:2000 IHC 1:50-1:200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C.Stable for 12 months from date of receipt
    有效期
    12 months
  • 抗原
    Norrie Disease (Pseudoglioma) (NDP)
    别名
    NDP (NDP 产品)
    别名
    EVR2 antibody, FEVR antibody, ND antibody, evr2 antibody, fevr antibody, xnorrin antibody, Ndph antibody, RGD1563968 antibody, NDP, norrin cystine knot growth factor antibody, Norrie disease (pseudoglioma) L homeolog antibody, Norrie disease (pseudoglioma) (human) antibody, NDP antibody, ndp.L antibody, Ndp antibody
    背景

    Description: Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.

    Gene: NDP

    分子量
    15kDa
    基因ID
    4693
    UniProt
    Q00604
    途径
    Sensory Perception of Sound
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