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ERCC1 抗体 (N-Term)

This anti-ERCC1 antibody is a 兔 多克隆 antibody detecting ERCC1 in WB. Suitable for 人, 小鼠, 大鼠, 犬, 豚鼠 和 兔.
产品编号 ABIN2786445
发货至: 中国

Quick Overview for ERCC1 抗体 (N-Term) (ABIN2786445)

抗原

See all ERCC1 抗体
ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

适用

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人, 小鼠, 大鼠, 犬, 豚鼠, 兔

宿主

  • 71
  • 44
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克隆类型

  • 66
  • 51
多克隆

标记

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This ERCC1 antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 抗原表位

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    N-Term

    序列

    TVDTSAQAAP QTYAEYAISQ PLEGAGATCP TGSEPLAGET PNQALKPGAK

    预测反应

    Dog: 86%, Guinea Pig: 79%, Human: 100%, Mouse: 85%, Rabbit: 79%, Rat: 79%

    产品特性

    This is a rabbit polyclonal antibody against ERCC1. It was validated on Western Blot.

    纯化方法

    Affinity Purified

    免疫原

    The immunogen is a synthetic peptide directed towards the N-terminal region of human ERCC1
  • 限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeat freeze-thaw cycles.

    储存条件

    -20 °C

    储存方法

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原

    ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

    别名

    ERCC1

    背景

    The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.
    Alias Symbols: UV20, COFS4, RAD10
    Protein Size: 213

    分子量

    23 kDa

    基因ID

    2067

    NCBI登录号

    NM_001166049, NP_001159521

    UniProt

    P07992

    途径

    DNA Damage Repair, Production of Molecular Mediator of Immune Response
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