Sphingomyelin Synthase 1 抗体 (Middle Region)
(1 reference)Quick Overview for Sphingomyelin Synthase 1 抗体 (Middle Region) (ABIN2786225)
抗原
See all Sphingomyelin Synthase 1 (SGMS1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- LTTVMISVVH ERVPPKEVQP PLPDTFFDHF NRVQWAFSIC EINGMILVGL
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 77%
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产品特性
- This is a rabbit polyclonal antibody against Sgms1. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of Mouse Sgms1
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anti-Sphingomyelin Synthase 1 (SGMS1) (AA 331-413) antibody
SGMS1 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Sphingomyelin Synthase 1 (SGMS1) (AA 48-137) antibodySGMS1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sphingomyelin Synthase 1 (SGMS1) (AA 1-134) antibodySGMS1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Sphingomyelin Synthase 1 (SGMS1) antibodySGMS1 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Sphingomyelin Synthase 1 (SGMS1) (AA 144-193) antibodySGMS1 适用: 人, 小鼠, 大鼠, 兔, Cow, 犬, 豚鼠, 马, Bat, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Sphingomyelin Synthase 1 (SGMS1) (AA 24-53), (N-Term) antibodySGMS1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB32319 unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 419 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "Mass Spectrometry Imaging Reveals Elevated Glomerular ATP/AMP in Diabetes/obesity and Identifies Sphingomyelin as a Possible Mediator." in: EBioMedicine, Vol. 7, pp. 121-34, (2016) (PubMed).
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: "Mass Spectrometry Imaging Reveals Elevated Glomerular ATP/AMP in Diabetes/obesity and Identifies Sphingomyelin as a Possible Mediator." in: EBioMedicine, Vol. 7, pp. 121-34, (2016) (PubMed).
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- Sphingomyelin Synthase 1 (SGMS1)
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别名
- Sgms1
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背景
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Bidirectional lipid cholinephosphotransferase is capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Sgms1 directly and specifically recognizes the choline head group on the substrate. It also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Sgms1 does not function strictly as a SM synthase and suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. Sgms1 may protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.
Alias Symbols: 9530058O11Rik, AI841905, C80702, MGC30540, Mob, Sms1, Sor1, Tmem23
Protein Size: 419 -
分子量
- 46 kDa
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基因ID
- 208449
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NCBI登录号
- NM_144792, NP_659041
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UniProt
- Q8VCQ6
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途径
- Cellular Response to Molecule of Bacterial Origin
抗原
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