ITGB3BP 抗体 (N-Term)
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北京 101111
Quick Overview for ITGB3BP 抗体 (N-Term) (ABIN2785998)
抗原
See all ITGB3BP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- ITGB3BP Antibody - N-terminal region
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序列
- TGTCQMSLFA SPTSSEEQKH RNGLSNEKRK KLNHPSLTES KESTTKDNDE
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预测反应
- Human: 100%
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产品特性
- This is a rabbit polyclonal antibody against ITGB3BP. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human ITGB3BP
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anti-Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP) (AA 1-100) antibody
ITGB3BP 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3F6 unconjugated
anti-Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP) antibodyITGB3BP 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP) (Internal Region) antibodyITGB3BP 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP) (AA 1-177) antibodyITGB3BP 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP) antibodyITGB3BP 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP) (AA 36-85) antibodyITGB3BP 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP) (AA 1-111) antibodyITGB3BP 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP54999-100UG
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- prevent freeze-thaw cycles
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储存条件
- 4 °C,-20 °C
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储存方法
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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- ITGB3BP (Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP))
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别名
- ITGB3BP
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背景
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Background Information: ITGB3BP is a transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. ITGB3BP acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. It induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. ITGB3BP may also act as an inhibitor of cyclin A-associated kinase. ITGB3BP may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
Gene Name: Integrin beta 3 binding protein (beta3-endonexin)
Alternative Symbols: CENPR, NRIF3, TAP20, CENP-R, HSU37139
Protein Name: Centromere protein R
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分子量
- 20kDa
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基因ID
- 23421
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NCBI登录号
- NP_055103
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UniProt
- Q13352
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途径
- Neurotrophin Signaling Pathway
抗原
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