RPSA/Laminin Receptor 抗体 (Middle Region)
Quick Overview for RPSA/Laminin Receptor 抗体 (Middle Region) (ABIN2785828)
抗原
See all RPSA/Laminin Receptor (RPSA) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- TFTNQIQAAF REPRLLVVTD PRADHQPLTE ASYVNLPTIA LCNTDSPLRY
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预测反应
- Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%
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产品特性
- This is a rabbit polyclonal antibody against RPSA. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human RPSA
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anti-Ribosomal Protein SA (RPSA) antibody
RPSA 适用: 人 WB, IHC, IF, FACS, StM 宿主: 小鼠 Monoclonal RPSA-2699 unconjugated
anti-Ribosomal Protein SA (RPSA) (AA 1-295) antibodyRPSA 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein SA (RPSA) antibodyRPSA 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein SA (RPSA) (AA 101-200) antibodyRPSA 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), FACS, IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein SA (RPSA) (AA 107-156) antibodyRPSA 适用: 人, 小鼠, 大鼠, Cow, 绵羊, Pig, 小鸡, 犬, 山羊, 马, 兔, 斑马鱼, 豚鼠, 非洲爪蟾, Hamster, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein SA (RPSA) (AA 196-295) antibodyRPSA 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 8G4 unconjugated
anti-Ribosomal Protein SA (RPSA) (N-Term) antibodyRPSA 适用: 人, 小鼠, 大鼠, Cow, 绵羊, Pig, 小鸡, 犬, 山羊, 马, 兔, 豚鼠, 非洲爪蟾, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein SA (RPSA) antibodyRPSA 适用: 人, 小鼠, Cow, 小鸡, 非洲爪蟾 WB, ELISA, IHC (p), IP, ICC, ICFC 宿主: 小鼠 Monoclonal RP-01 unconjugated
anti-Ribosomal Protein SA (RPSA) (AA 2-294) antibodyRPSA 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 295 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- RPSA/Laminin Receptor (RPSA) (Ribosomal Protein SA (RPSA))
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别名
- RPSA
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背景
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RPSA is required for the assembly and/or stability of the 40S ribosomal subunit. RPSA is also required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. RPSA plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. RPSA may play a role in cell fate determination and tissue morphogenesis. RPSA also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria.Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
Alias Symbols: 37LRP, 67LR, LAMBR, LAMR1, LRP, p40, SA, LBP, lamR, LRP/LR, LBP/p40, NEM/1CHD4
Protein Interaction Partner: UBC, SUMO2, MDM2, ZBTB1, RNF2, SUP35, rev, SYNCRIP, GNB2L1, DYNLL1, RPS28, RPS23, RPS21, RPS20, RPS18, RPS16, RPS13, RPS12, RPS9, RPS8, RPS5, RPS4X, RPS3A, RPS3, FAU, DYNC1LI2, PTBP1, PRUNE2, TSR1, XRCC6, HNRNPD, TARDBP, UBD, BAG3, PROS1, NKX3-1, ITGA4, I
Protein Size: 295 -
分子量
- 33 kDa
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基因ID
- 3921
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NCBI登录号
- NM_002295, NP_002286
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UniProt
- P08865
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途径
- Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
抗原
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