GCAP1 抗体 (N-Term)
Quick Overview for GCAP1 抗体 (N-Term) (ABIN2785648)
抗原
See all GCAP1 (GUCA1A) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- LYEFRQFFGL KNLSPSASQY VEQMFETFDF NKDGYIDFME YVAALSLVLK
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预测反应
- Cow: 93%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 93%, Rat: 100%
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产品特性
- This is a rabbit polyclonal antibody against GUCA1A. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human GUCA1A
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anti-Guanylate Cyclase Activator 1A (Retina) (GUCA1A) (AA 1-93) antibody
GUCA1A 适用: 人 ELISA, WB, RNAi 宿主: 小鼠 Monoclonal 2F7 unconjugated
anti-Guanylate Cyclase Activator 1A (Retina) (GUCA1A) antibodyGUCA1A 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Cyclase Activator 1A (Retina) (GUCA1A) (AA 36-85) antibodyGUCA1A 适用: 人, 小鼠, 大鼠, 犬, 马, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Cyclase Activator 1A (Retina) (GUCA1A) (C-Term) antibodyGUCA1A 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Cyclase Activator 1A (Retina) (GUCA1A) (AA 160-191), (C-Term) antibodyGUCA1A 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 201 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- GCAP1 (GUCA1A) (Guanylate Cyclase Activator 1A (Retina) (GUCA1A))
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别名
- GUCA1A
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背景
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GUCA1A(GCAP1) plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3), a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations, causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia.
Alias Symbols: COD3, GCAP, GCAP1, GUCA, GUCA1, CORD14, C6orf131, dJ139D8.6
Protein Interaction Partner: GUCY2D,
Protein Size: 201 -
分子量
- 23 kDa
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基因ID
- 2978
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NCBI登录号
- NM_000409, NP_000400
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UniProt
- P43080
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途径
- Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
抗原
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