GCAP1 抗体 (N-Term)
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- 抗原 See all GCAP1 (GUCA1A) 抗体
- GCAP1 (GUCA1A) (Guanylate Cyclase Activator 1A (Retina) (GUCA1A))
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抗原表位
- N-Term
- 适用
- 人, 小鼠, 大鼠, 犬, 马, Cow, 豚鼠, Pig, 兔
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GCAP1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- LYEFRQFFGL KNLSPSASQY VEQMFETFDF NKDGYIDFME YVAALSLVLK
- 预测反应
- Cow: 93%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 93%, Rat: 100%
- 产品特性
- This is a rabbit polyclonal antibody against GUCA1A. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human GUCA1A
- Top Product
- Discover our top product GUCA1A Primary Antibody
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anti-Guanylate Cyclase Activator 1A (Retina) (GUCA1A) (AA 1-93) antibody
GUCA1A 适用: 人 ELISA, WB, RNAi 宿主: 小鼠 Monoclonal 2F7 unconjugated
anti-Guanylate Cyclase Activator 1A (Retina) (GUCA1A) antibodyGUCA1A 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Cyclase Activator 1A (Retina) (GUCA1A) (AA 36-85) antibodyGUCA1A 适用: 人, 小鼠, 大鼠, 犬, 马, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Cyclase Activator 1A (Retina) (GUCA1A) (AA 160-191), (C-Term) antibodyGUCA1A 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Cyclase Activator 1A (Retina) (GUCA1A) (C-Term) antibodyGUCA1A 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 201 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- GCAP1 (GUCA1A) (Guanylate Cyclase Activator 1A (Retina) (GUCA1A))
- 别名
- GUCA1A (GUCA1A 产品)
- 背景
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GUCA1A(GCAP1) plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3), a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations, causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia.
Alias Symbols: COD3, GCAP, GCAP1, GUCA, GUCA1, CORD14, C6orf131, dJ139D8.6
Protein Interaction Partner: GUCY2D,
Protein Size: 201 - 分子量
- 23 kDa
- 基因ID
- 2978
- NCBI登录号
- NM_000409, NP_000400
- UniProt
- P43080
- 途径
- Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
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