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- 抗原 See all GCAP1 (GUCA1A) 抗体
- GCAP1 (GUCA1A) (Guanylate Cyclase Activator 1A (Retina) (GUCA1A))
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抗原表位
- AA 160-191, C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GCAP1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
- 免疫原
- This GCAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-191 amino acids from the C-terminal region of human GCAP1.
- 亚型
- Ig Fraction
- Top Product
- Discover our top product GUCA1A Primary Antibody
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anti-Guanylate Cyclase Activator 1A (Retina) (GUCA1A) (AA 1-93) antibody
GUCA1A 适用: 人 ELISA, WB, RNAi 宿主: 小鼠 Monoclonal 2F7 unconjugated
anti-Guanylate Cyclase Activator 1A (Retina) (GUCA1A) (C-Term) antibodyGUCA1A 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Cyclase Activator 1A (Retina) (GUCA1A) antibodyGUCA1A 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Cyclase Activator 1A (Retina) (GUCA1A) (AA 36-85) antibodyGUCA1A 适用: 人, 小鼠, 大鼠, 犬, 马, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Cyclase Activator 1A (Retina) (GUCA1A) (C-Term) antibodyGUCA1A 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100 - 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- 抗原
- GCAP1 (GUCA1A) (Guanylate Cyclase Activator 1A (Retina) (GUCA1A))
- 别名
- GCAP1 (GUCA1A 产品)
- 别名
- C6orf131 antibody, COD3 antibody, CORD14 antibody, GCAP antibody, GCAP1 antibody, GUCA antibody, GUCA1 antibody, dJ139D8.6 antibody, MGC84170 antibody, GUCA1A antibody, guca1a antibody, MGC146317 antibody, GC-A antibody, Gcap1 antibody, Guca1 antibody, mGCAP1 antibody, gcap1 antibody, guanylate cyclase activator 1A antibody, guanylate cyclase activator 1A L homeolog antibody, guanylate cyclase activator 1A (retina) antibody, guanylate cyclase activator 1a (retina) antibody, GUCA1A antibody, Guca1a antibody, guca1a.L antibody, guca1a antibody
- 背景
- Guanylate cyclase-activating protein is a l Ca(2+)-binding protein that upregulates synthesis of cGMP in photoreceptors. The known mammalian GCAPs are more than 90 % similar, consisting of 201 to 205 amino acids, and containing 3 identically conserved Ca(2+)-binding sites. The GUCA1A gene, also termed GCAP1, is transcribed into a single 1.7-kb mRNA species detectable only in the retina. In a 4-generation British family with typical clinical features of autosomal dominant cone dystrophy a tyr99-to-cys mutation) in the GUCA1A gene has been identified. Another family with a pro50-to-leu mutation in GUCA1A demonstrated phenotypic variability ranging from mild photophobia to rod-cone dystrophy. The mutant protein could activate guanylate cyclase 1 (GUCY2D) and displayed similar calcium sensitivity to wildtype protein. However, there was a marked increase in the susceptibility to protease degradation and a reduction in the thermal stability of the pro50-to-leu mutation, which may depress cellular concentration and thereby contribute to retinal cell mortality.
- 分子量
- 23 kDa
- 基因ID
- 2978
- UniProt
- P43080
- 途径
- Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
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