ULK1 抗体 (N-Term)
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- 抗原 See all ULK1 抗体
- ULK1 (Unc-51 Like Kinase 1 (ULK1))
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抗原表位
- N-Term
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适用
- 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ULK1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- PEVIMSQHYD GKADLWSIGT IVYQCLTGKA PFQASSPQDL RLFYEKNKTL
- 预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
- 产品特性
- This is a rabbit polyclonal antibody against ULK1. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N-terminal region of Human ULK1
- Top Product
- Discover our top product ULK1 Primary Antibody
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anti-Unc-51 Like Kinase 1 (ULK1) (AA 951-1050) antibody
ULK1 适用: 人, 小鼠, 大鼠 ELISA, WB, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Unc-51 Like Kinase 1 (ULK1) (AA 602-715) antibodyULK1 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 2H8 unconjugated
anti-Unc-51 Like Kinase 1 (ULK1) (AA 400-499) antibodyULK1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Unc-51 Like Kinase 1 (ULK1) antibodyULK1 适用: 人, 小鼠 ELISA, WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Unc-51 Like Kinase 1 (ULK1) (pSer556) antibodyULK1 适用: 人, 小鼠, 大鼠 ELISA, WB, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Unc-51 Like Kinase 1 (ULK1) (AA 567-577) antibodyULK1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Unc-51 Like Kinase 1 (ULK1) (AA 567-577) antibody (APC)ULK1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal APC
anti-Unc-51 Like Kinase 1 (ULK1) (AA 567-577) antibody (Atto 488)ULK1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal Atto 488
anti-Unc-51 Like Kinase 1 (ULK1) (AA 567-577) antibody (Atto 594)ULK1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal Atto 594
anti-Unc-51 Like Kinase 1 (ULK1) (AA 567-577) antibody (Atto 390)ULK1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal Atto 390
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeat freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- ULK1 (Unc-51 Like Kinase 1 (ULK1))
- 别名
- ULK1 (ULK1 产品)
- 别名
- ATG1 antibody, ATG1A antibody, UNC51 antibody, Unc51.1 antibody, hATG1 antibody, si:dkey-11o18.7 antibody, ulk1 antibody, ULK1 antibody, AU041434 antibody, mKIAA0722 antibody, zgc:195008 antibody, unc-51 like autophagy activating kinase 1 antibody, unc-51 like kinase 1 antibody, unc-51 like autophagy activating kinase 1a antibody, ULK1 antibody, Ulk1 antibody, ulk1b antibody, ulk1a antibody
- 背景
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ULK1 is a serine/threonine-protein kinase involved in autophagy in response to starvation. It acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. It is activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. It may phosphorylate ATG13/KIAA0652 and RPTOR, however such data need additional evidences and plays a role early in neuronal differentiation and is required for granule cell axon formation.
Alias Symbols: ATG1, ATG1A, UNC51, Unc51.1, hATG1
Protein Interaction Partner: SESN2, SQSTM1, ATG16L1, EXOC8, EXOC2, BECN1, RALB, AMBRA1, ULK1, UBC, TRAF6, MBP, ATG13, MAP1LC3C, MAP1LC3A, MAP1LC3B, GABARAPL1, GABARAPL2, GABARAP, MLST8, RPTOR, MTOR, PPP1CA, ATG4B, CDC37, G3BP1, RB1CC1, USP10, PRKAG1, PRKAB2, PRKAA2, PRKAA1, SYNGAP1,
Protein Size: 1050 - 分子量
- 112 kDa
- 基因ID
- 8408
- NCBI登录号
- NM_003565, NP_003556
- UniProt
- O75385
- 途径
- Regulation of Cell Size, Autophagy
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