POLI 抗体 (N-Term)
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Quick Overview for POLI 抗体 (N-Term) (ABIN2784869)
抗原
See all POLI 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- PVVERLGFDE NFVDLTEMVE KRLQQLQSDE LSAVTVSGHV YNNQSINLLD
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 82%, Zebrafish: 86%
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产品特性
- This is a rabbit polyclonal antibody against POLI. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human POLI
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anti-Polymerase (DNA Directed) iota (POLI) (AA 616-715) antibody
POLI 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 8G9 unconjugated
anti-Polymerase (DNA Directed) iota (POLI) (N-Term) antibodyPOLI 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed) iota (POLI) (AA 458-711) antibodyPOLI 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed) iota (POLI) (N-Term) antibodyPOLI 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed) iota (POLI) (AA 458-740) antibodyPOLI 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 1B9 unconjugated
anti-Polymerase (DNA Directed) iota (POLI) (AA 51-150) antibodyPOLI 适用: 大鼠 ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed) iota (POLI) (C-Term) antibodyPOLI 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed) iota (POLI) (AA 143-192) antibodyPOLI 适用: 人, 大鼠, 小鼠, Cow, 犬, 豚鼠, 马, 斑马鱼, Bat, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed) iota (POLI) (AA 673-701), (C-Term) antibodyPOLI 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 740 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- POLI (Polymerase (DNA Directed) iota (POLI))
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别名
- POLI
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背景
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POLI is an error-prone DNA polymerase specifically involved in DNA repair.POLI plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls.POLI favors Hoogsteen base-pairing in the active site.POLI inserts the correct base with high-fidelity opposite an adenosine template.POLI exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine.POLI may play a role in hypermutation of immunogobulin genes.POLI forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
Alias Symbols: RAD30B, RAD3OB
Protein Interaction Partner: TMEM239, TRIM39, ZBTB44, UBC, TRAF6, DAZAP2, RNF11, TRIM23, POLH, PCNA, APP, REV1, XRCC1, UBB, UBA52, CALCOCO2, DVL2,
Protein Size: 740 -
分子量
- 83 kDa
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基因ID
- 11201
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NCBI登录号
- NM_007195, NP_009126
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UniProt
- Q9UNA4
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途径
- DNA Damage Repair
抗原
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