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POLR3C 抗体 (Middle Region)

This anti-POLR3C antibody is a 兔 多克隆 antibody detecting POLR3C in WB. Suitable for 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔 和 Saccharomyces cerevisiae.
产品编号 ABIN2784816
发货至: 中国

Quick Overview for POLR3C 抗体 (Middle Region) (ABIN2784816)

抗原

See all POLR3C 抗体
POLR3C (Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C))

适用

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人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, Saccharomyces cerevisiae

宿主

  • 45
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克隆类型

  • 48
  • 1
多克隆

标记

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This POLR3C antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 抗原表位

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    Middle Region

    序列

    VEAIIASMQA TGAEEAQLQE IEEMITAPER QQLETLKRNV NKLDASEIQV

    预测反应

    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 90%

    产品特性

    This is a rabbit polyclonal antibody against POLR3C. It was validated on Western Blot.

    纯化方法

    Affinity Purified

    免疫原

    The immunogen is a synthetic peptide directed towards the middle region of human POLR3C
  • 应用备注

    Optimal working dilutions should be determined experimentally by the investigator.

    说明

    Antigen size: 534 AA

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    Lot specific

    缓冲液

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze-thaw cycles.

    储存条件

    -20 °C

    储存方法

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原

    POLR3C (Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C))

    别名

    POLR3C

    背景

    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. POLR3C is a specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. POLR3C may direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. POLR3C may be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. POLR3C plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses.POLR3C acts as nuclear and cytosolic DNA sensor involved in innate immune response. POLR3C can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
    Alias Symbols: RPC3, RPC62
    Protein Interaction Partner: PNMA5, CEP63, ROPN1, TNR, ROCK1, TRIM27, UBC, VCP, POLR1C, POLR2E, APP, POLR3H, NOC4L, RSL1D1, POLR3A, POLR3G, POLR3F, GTF3C4, POLR3D, TBP, GTF3C3, GTF3C5, GTF3C2, GTF3C1,
    Protein Size: 534

    分子量

    60 kDa

    基因ID

    10623

    NCBI登录号

    NM_006468, NP_006459

    UniProt

    Q9BUI4
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