POLR3C 抗体 (Middle Region)
Quick Overview for POLR3C 抗体 (Middle Region) (ABIN2784816)
抗原
See all POLR3C 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- Middle Region
-
序列
- VEAIIASMQA TGAEEAQLQE IEEMITAPER QQLETLKRNV NKLDASEIQV
-
预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 90%
-
产品特性
- This is a rabbit polyclonal antibody against POLR3C. It was validated on Western Blot.
-
纯化方法
- Affinity Purified
-
免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human POLR3C
-
-
anti-Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C) antibody
POLR3C 适用: 人 WB, IF, IHC (p), IHC 宿主: 小鼠 Monoclonal 2H1 unconjugated
anti-Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C) (AA 1-534) antibodyPOLR3C 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C) (AA 1-534) antibodyPOLR3C 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C) (Internal Region) antibodyPOLR3C 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C) (AA 1-534) antibodyPOLR3C 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C) antibodyPOLR3C 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C) (C-Term) antibodyPOLR3C 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C) (AA 1-270) antibodyPOLR3C 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C) (AA 202-230) antibodyPOLR3C 适用: 人 WB 宿主: 兔 Polyclonal RB36947 unconjugated
-
-
应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
-
说明
-
Antigen size: 534 AA
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- Lot specific
-
缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freeze-thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
-
- POLR3C (Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C))
-
别名
- POLR3C
-
背景
-
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. POLR3C is a specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. POLR3C may direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. POLR3C may be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. POLR3C plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses.POLR3C acts as nuclear and cytosolic DNA sensor involved in innate immune response. POLR3C can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
Alias Symbols: RPC3, RPC62
Protein Interaction Partner: PNMA5, CEP63, ROPN1, TNR, ROCK1, TRIM27, UBC, VCP, POLR1C, POLR2E, APP, POLR3H, NOC4L, RSL1D1, POLR3A, POLR3G, POLR3F, GTF3C4, POLR3D, TBP, GTF3C3, GTF3C5, GTF3C2, GTF3C1,
Protein Size: 534 -
分子量
- 60 kDa
-
基因ID
- 10623
-
NCBI登录号
- NM_006468, NP_006459
-
UniProt
- Q9BUI4
抗原
-
