UBA3 抗体 (N-Term)
Quick Overview for UBA3 抗体 (N-Term) (ABIN2784205)
抗原
See all UBA3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- EGRWNHVKKF LERSGPFTHP DFEPSTESLQ FLLDTCKVLV IGAGGLGCEL
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预测反应
- Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%
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产品特性
- This is a rabbit polyclonal antibody against UBA3. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human UBA3
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anti-Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) (AA 415-445), (C-Term) antibody
UBA3 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB2803 unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) (Internal Region) antibodyUBA3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) antibodyUBA3 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) (AA 409-448), (C-Term) antibodyUBA3 适用: 人, 小鼠, 大鼠 WB, IHC, FACS, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) antibodyUBA3 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) (AA 234-463), (Catalytic Subunit) antibodyUBA3 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) (AA 35-84) antibodyUBA3 适用: 人, 小鼠, 大鼠, Cow, 犬, 斑马鱼, 马, Pig, 兔, 小鸡, Bat, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) (AA 1-229) antibodyUBA3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) (N-Term) antibodyUBA3 适用: 人, 小鼠, 大鼠, Cow, 犬, 斑马鱼, 小鸡, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) (C-Term) antibodyUBA3 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 463 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- UBA3 (Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3))
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别名
- UBA3
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背景
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UBA3 is a catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. UBA3 down-regulates steroid receptor activity. UBA3 is necessary for cell cycle progression.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Alias Symbols: DKFZp566J164, MGC22384, UBE1C, hUBA3
Protein Interaction Partner: UBA3, UBC, IMPA2, CPNE2, NEDD8, CAMK1D, NSFL1C, DCPS, KDM1A, PAPSS1, NAE1, XPO1, PCYT2, CAPN2, AHCY, ACAT2, NT5DC1, NUDCD2, TXNDC17, WDR61, UFC1, DSTN, VCL, UBE2H, PRDX2, TWF1, UBE2M, UIMC1, CHD3,
Protein Size: 463 -
分子量
- 52 kDa
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基因ID
- 9039
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NCBI登录号
- NM_003968, NP_003959
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UniProt
- Q8TBC4
抗原
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