我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

MAVS 抗体 (N-Term)

Name: MAVS 抗体 (N-Term)
SKU: ABIN2783802
Availability: OutOfStock

This anti-MAVS antibody is a 兔多克隆 antibody detecting MAVS in WB 和 IHC. Suitable for 人, 小鼠和 Cow.

WB Suggested Anti-VISA Antibody Titration: 0. (MAVS 抗体 (N-Term))

Sample Type : 1: 20ug HEK293T no transfection, 2: 20ug HEK293T 3Flag-MAVS/VISA Primary Antibody Dilution : 1:1000 Secondary Antibody : Anti-rabbit HRP Secondary Antibody Dilution : 1:1000 Color/Signal Descriptions : ARP49558-QC17479-WB-image-02 Gene Name : VISA Submitted by : Dr. (MAVS 抗体 (N-Term))

IHC

3 images

产品编号 ABIN2783802

发货至: 中国

Quick Overview for MAVS 抗体 (N-Term) (ABIN2783802)

抗原

See all MAVS 抗体

MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))

适用

人, 小鼠, Cow

宿主

兔

克隆类型

多克隆

标记

This MAVS antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC)

Discover our top product MAVS Primary Antibody

抗原表位
15

8

8

4

4

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1
N-Term

序列

ETQAPESPGE NSEQALQTLS PRAIPRNPDG GPLESSSDLA ALSPLTSSGH

预测反应

Cow: 79%, Human: 100%, Mouse: 79%

产品特性

This is a rabbit polyclonal antibody against VISA. It was validated on Western Blot using a cell lysate as a positive control.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide directed towards the N terminal region of human VISA
anti-Mitochondrial Antiviral Signaling Protein (MAVS) (AA 1-65) antibody
MAVS 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Mitochondrial Antiviral Signaling Protein (MAVS) (AA 34-96) antibody
MAVS 适用: 人 WB, IHC, ICC, IHC (fro), FACS 宿主: 兔 Polyclonal unconjugated

anti-Mitochondrial Antiviral Signaling Protein (MAVS) (C-Term) antibody
MAVS 适用: 人, 小鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Mitochondrial Antiviral Signaling Protein (MAVS) (AA 1-540) antibody
MAVS 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated

anti-Mitochondrial Antiviral Signaling Protein (MAVS) (AA 160-450) antibody
MAVS 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal Adri-1 unconjugated

anti-Mitochondrial Antiviral Signaling Protein (MAVS) (AA 470-519) antibody
MAVS 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Mitochondrial Antiviral Signaling Protein (MAVS) (AA 146-195) antibody
MAVS 适用: 人, 小鼠, Cow WB 宿主: 兔 Polyclonal unconjugated

anti-Mitochondrial Antiviral Signaling Protein (MAVS) (AA 1-30), (N-Term) antibody
MAVS 适用: 小鼠 WB 宿主: 兔 Polyclonal RB42373 unconjugated

anti-Mitochondrial Antiviral Signaling Protein (MAVS) (AA 477-505) antibody
MAVS 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Mitochondrial Antiviral Signaling Protein (MAVS) (AA 1-30) antibody
MAVS 适用: 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 896 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
抗原

MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))

别名

VISA

背景

Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 or by the cytoplasmic RNA helicases MDA5 and RIGI (ROBO3). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK) and IKKB (IKBKB), which activate NFKB, or TBK1 and IKKE (IKBKE), which activate IRF3. Activated IRF3 and NFKB induce transcription of IFNB (IFNB1). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1). For RIGI, the intermediary protein is mitochondria-bound VISA. Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3, MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK, MIM 600664) and IKKB (IKBKB, MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE, MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1, MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1, MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005 [PubMed 16239922]).[supplied by OMIM]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CARDIF, DKFZp666M015, FLJ27482, FLJ41962, IPS-1, KIAA1271, MAVS, IPS1, VISA
Protein Interaction Partner: MIB2, KCNIP3, DDX58, UBC, TRAF6, TRAF3, UBXN1, TMEM173, SMURF2, HCVgp1, AMFR, MFN1, MFN2, MUL1, TOMM70A, FLOT2, NDFIP1, SMURF1, TBK1, IKBKG, TICAM1, TRAF2, MAP3K7, SRC, IRF7, IRF3, IKBKE, TSPAN6, RARRES3, ECSIT, PCBP2, ITCH, IFIH1, PSMA7, WDR5, HECTD3, PD
Protein Size: 896

分子量

56 kDa

基因ID

57506

NCBI登录号

NM_020746, NP_065797

UniProt

Q2HWT5

途径

Activation of Innate immune Response, Inositol Metabolic Process, Hepatitis C