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DNMT3B 抗体 (Middle Region)

Name: DNMT3B 抗体 (Middle Region)
SKU: ABIN2783648
Availability: OutOfStock

This anti-DNMT3B antibody is a 兔多克隆 antibody detecting DNMT3B in WB. Suitable for 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔和斑马鱼.

WB Suggested Anti-DNMT3B Antibody Titration: 0. (DNMT3B 抗体 (Middle Region))

Sample Type : Lane 1: 20ug mouse mesenchymal stem cell lysate Primary Antibody Dilution : 1:2000 Secondary Antibody: Anti-rabbit-HRP Secondary Antibody Dilution: 1:10,000 Color/Signal Descriptions: DNMT3B Gene Name: Anonymous Submitted by: (DNMT3B 抗体 (Middle Region))

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产品编号 ABIN2783648

发货至: 中国

Datasheet as PDF

Quick Overview for DNMT3B 抗体 (Middle Region) (ABIN2783648)

抗原

See all DNMT3B 抗体

DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))

适用

人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼

宿主

兔

克隆类型

多克隆

标记

This DNMT3B antibody is un-conjugated

应用范围

Western Blotting (WB)

Discover our top product DNMT3B Primary Antibody

抗原表位
17

16

8

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7

3

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Middle Region

序列

GTGRLFFEFY HLLNYSRPKE GDDRPFFWMF ENVVAMKVGD KRDISRFLEC

预测反应

Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

产品特性

This is a rabbit polyclonal antibody against DNMT3B. It was validated on Western Blot using a cell lysate as a positive control.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide directed towards the middle region of human DNMT3B
anti-DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) (AA 1-150) antibody
DNMT3B 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 7E5E9C1 unconjugated

anti-DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) (AA 1-150) antibody
DNMT3B 适用: 人 ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 4D1A2E5 unconjugated

anti-DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) (N-Term) antibody
DNMT3B 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) (AA 1-100) antibody
DNMT3B 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) (N-Term) antibody
DNMT3B 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) (AA 389-417) antibody
DNMT3B 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB01906 unconjugated

anti-DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) (AA 389-417) antibody
DNMT3B 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) (AA 1-80) antibody
DNMT3B 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc) 宿主: 兔 Polyclonal unconjugated

anti-DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) antibody
DNMT3B 适用: 人 WB, FACS, ICC, DB 宿主: 小鼠 Monoclonal 2280C3a unconjugated

anti-DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) (AA 1-50) antibody
DNMT3B 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 770 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
抗原

DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))

别名

DNMT3B

背景

DNMT3B is required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. DNMT3B may preferentially methylate nucleosomal DNA within the nucleosome core region. DNMT3B may function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. DNMT3B seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, DNMT3B is involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Six alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
Alias Symbols: ICF, M.HsaIIIB, ICF1
Protein Interaction Partner: RBBP7, RBBP4, HDAC2, HDAC1, CHD4, MTA2, MTA1, POLR2H, POLR2C, POLR2A, DNMT1, LEO1, CDC73, PAF1, RTF1, CTR9, NRIP1, EZH2, DNMT3L, SUZ12, SIRT1, EED, UBC, EPHB1, CREB1, CBX5, TRIM28, ZFP57, UHRF2, UHRF1, MAP1LC3B, UBE2W, PLEKHJ1, DUSP23, CMTM6, PAM16, TSC22
Protein Size: 770

分子量

86 kDa

基因ID

1789

NCBI登录号

NM_175849, NP_787045