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POLK 抗体 (Middle Region)

POLK 适用: 人, 小鼠, 大鼠, 马, Pig, Cow, 犬, 豚鼠, 兔 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2783506
发货至: 中国
  • 抗原 See all POLK 抗体
    POLK (Polymerase (DNA Directed) kappa (POLK))
    抗原表位
    • 15
    • 7
    • 6
    • 6
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    适用
    • 54
    • 14
    • 12
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, 马, Pig, Cow, 犬, 豚鼠, 兔
    宿主
    • 46
    • 5
    • 3
    克隆类型
    • 51
    • 3
    多克隆
    标记
    • 25
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This POLK antibody is un-conjugated
    应用范围
    • 28
    • 20
    • 14
    • 5
    • 4
    • 4
    • 2
    • 1
    Western Blotting (WB)
    序列
    ATECTLEKTD KDKFVKPLEM SHKKSFFDKK RSERKWSHQD TFKCEAVNKQ
    预测反应
    Cow: 100%, Dog: 100%, Guinea Pig: 79%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 86%, Rat: 100%
    产品特性
    This is a rabbit polyclonal antibody against POLK. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the middle region of human POLK
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 870 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原
    POLK (Polymerase (DNA Directed) kappa (POLK))
    别名
    POLK (POLK 产品)
    别名
    DINB1 antibody, DINP antibody, POLQ antibody, Dinb1 antibody, POLK antibody, si:ch211-254o18.3 antibody, DNA polymerase kappa antibody, polymerase (DNA directed) kappa antibody, polymerase (DNA directed), kappa antibody, polymerase (DNA directed) kappa L homeolog antibody, POLK antibody, Polk antibody, polk antibody, Tb11.01.0080 antibody, Tb11.01.0010 antibody, Tb11.01.0020 antibody, Tb11.01.0030 antibody, Tb11.01.0040 antibody, Tb11.01.0050 antibody, Tb11.12.0001 antibody, Tb11.12.0002 antibody, Tb11.12.0003 antibody, polk.L antibody, polk-1 antibody
    背景
    POLK belongs to the DNA polymerase type-Y family. It contains 2 Rad18-type zinc fingers and 1 umuC domain. POLK is a DNA polymerase specifically involved in DNA repair. It plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. It lacks 3'-5' proofreading exonuclease activity. POLK forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity.
    Alias Symbols: DINB1, DINP, POLQ
    Protein Interaction Partner: XPO7, MSH2, MCM6, MCM4, MSH6, TRAIP, UBC, REV1, Shprh, RAD18, PCNA, XRCC1, RPA1, POLD1,
    Protein Size: 870
    分子量
    99 kDa
    基因ID
    51426
    NCBI登录号
    NM_016218, NP_057302
    UniProt
    Q9UBT6
    途径
    DNA Damage Repair
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