POLK 抗体 (Middle Region)
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北京 101111
Quick Overview for POLK 抗体 (Middle Region) (ABIN2783506)
抗原
See all POLK 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- ATECTLEKTD KDKFVKPLEM SHKKSFFDKK RSERKWSHQD TFKCEAVNKQ
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 79%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 86%, Rat: 100%
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产品特性
- This is a rabbit polyclonal antibody against POLK. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human POLK
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anti-Polymerase (DNA Directed) kappa (POLK) (AA 1-472) antibody
POLK 适用: 人 WB, ELISA, IF, IHC (p), RNAi 宿主: 小鼠 Monoclonal 6F2 unconjugated
anti-Polymerase (DNA Directed) kappa (POLK) (AA 1-472) antibodyPOLK 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Polymerase (DNA Directed) kappa (POLK) (AA 1-473) antibodyPOLK 适用: 人 WB, ELISA, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 6F2 unconjugated
anti-Polymerase (DNA Directed) kappa (POLK) (AA 1-472) antibodyPOLK 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 4F12 unconjugated
anti-Polymerase (DNA Directed) kappa (POLK) antibodyPOLK 适用: 人, 小鼠, 大鼠 WB, IF/ICC 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed) kappa (POLK) (AA 1-100) antibodyPOLK 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed) kappa (POLK) (AA 227-337) antibodyPOLK 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed) kappa (POLK) (AA 1-472) antibodyPOLK 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Polymerase (DNA Directed) kappa (POLK) (AA 1-472) antibodyPOLK 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed) kappa (POLK) (AA 35-84) antibodyPOLK 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 870 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- POLK (Polymerase (DNA Directed) kappa (POLK))
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别名
- POLK
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背景
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POLK belongs to the DNA polymerase type-Y family. It contains 2 Rad18-type zinc fingers and 1 umuC domain. POLK is a DNA polymerase specifically involved in DNA repair. It plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. It lacks 3'-5' proofreading exonuclease activity. POLK forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity.
Alias Symbols: DINB1, DINP, POLQ
Protein Interaction Partner: XPO7, MSH2, MCM6, MCM4, MSH6, TRAIP, UBC, REV1, Shprh, RAD18, PCNA, XRCC1, RPA1, POLD1,
Protein Size: 870 -
分子量
- 99 kDa
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基因ID
- 51426
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NCBI登录号
- NM_016218, NP_057302
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UniProt
- Q9UBT6
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途径
- DNA Damage Repair
抗原
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