SNAP23 抗体 (N-Term)
Quick Overview for SNAP23 抗体 (N-Term) (ABIN2783437)
抗原
See all SNAP23 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- GIKTITMLDE QKEQLNRIEE GLDQINKDMR ETEKTLTELN KCCGLCVCPC
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预测反应
- Cow: 79%, Dog: 86%, Guinea Pig: 86%, Horse: 92%, Human: 100%, Mouse: 86%, Rabbit: 86%, Rat: 86%, Yeast: 83%, Zebrafish: 90%
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产品特性
- This is a rabbit polyclonal antibody against SNAP23. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human SNAP23
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 211 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- SNAP23 (Synaptosomal-Associated Protein, 23kDa (SNAP23))
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别名
- SNAP23
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背景
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SNAP23 is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene.Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene.
Alias Symbols: HsT17016, SNAP23A, SNAP23B, SNAP-23
Protein Interaction Partner: VAMP5, SNAP23, STX11, UBC, NAPB, STX1A, FN1, ILF2, HNRNPAB, ANXA3, C12orf57, UBQLN2, SCFD1, SYNCRIP, FAM3C, YES1, STX4, SRSF1, PSAP, CEP97, CCP110, ELAVL1, WASH2P, MATR3, NSF, STX3, TLK1, SCGN, ABI2, STX6, KIF5B, STXBP5, SNAPIN, SCAMP2, SCAMP1, STX12, ABI
Protein Size: 211 -
分子量
- 23 kDa
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基因ID
- 8773
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NCBI登录号
- NM_003825, NP_003816
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UniProt
- O00161
抗原
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