IDH2 抗体 (Middle Region)
(1 reference)Quick Overview for IDH2 抗体 (Middle Region) (ABIN2783282)
抗原
See all IDH2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- GGTVFREPII CKNIPRLVPG WTKPITIGRH AHGDQYKATD FVADRAGTFK
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 93%, Zebrafish: 100%
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产品特性
- This is a rabbit polyclonal antibody against IDH2. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human IDH2
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anti-Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) (AA 40-452) antibody
IDH2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) (AA 193-452) antibodyIDH2 适用: 人 WB, IP, IF, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) (AA 1-143) antibodyIDH2 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 3E8E9 unconjugated
anti-Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) (AA 354-451) antibodyIDH2 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 5F11 unconjugated
anti-Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) (AA 413-447), (C-Term) antibodyIDH2 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) (AA 354-452) antibodyIDH2 适用: 人 WB, IHC, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 5F11 unconjugated
anti-Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) (AA 251-350) antibodyIDH2 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) (AA 193-452) antibodyIDH2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) (Internal Region) antibodyVerified IDH2 适用: 人, 小鼠, 大鼠, Pig WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) (AA 354-451) antibodyIDH2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 452 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "Elevated CO(2) levels cause mitochondrial dysfunction and impair cell proliferation." in: The Journal of biological chemistry, Vol. 286, Issue 43, pp. 37067-76, (2011) (PubMed).
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: "Elevated CO(2) levels cause mitochondrial dysfunction and impair cell proliferation." in: The Journal of biological chemistry, Vol. 286, Issue 43, pp. 37067-76, (2011) (PubMed).
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- IDH2 (Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2))
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别名
- IDH2
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背景
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Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. IDH2 is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ICD-M, IDH, IDHM, IDP, mNADP-IDH, IDPM, D2HGA2
Protein Interaction Partner: UBC, SUMO1, NEDD8, MDM2, ADRB2, HDAC1, PYGL, CDK2, SLC2A4,
Protein Size: 452 -
分子量
- 47 kDa
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基因ID
- 3418
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NCBI登录号
- NM_002168, NP_002159
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UniProt
- P48735
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途径
- Warburg Effect
抗原
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