GP6 抗体 (Middle Region)
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北京 101111
Quick Overview for GP6 抗体 (Middle Region) (ABIN2782886)
抗原
See all GP6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- PPSPVAEFSE ATAELTVSFT NEVFTTETSR SITASPKESD SPAGPARQYY
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预测反应
- Human: 100%
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产品特性
- This is a rabbit polyclonal antibody against GP6. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human GP6
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anti-Glycoprotein VI (Platelet) (GP6) (AA 86-231) antibody
GP6 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glycoprotein VI (Platelet) (GP6) (AA 115-265) antibodyGP6 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glycoprotein VI (Platelet) (GP6) (AA 309-337), (C-Term) antibodyGP6 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB22884 unconjugated
anti-Glycoprotein VI (Platelet) (GP6) antibodyGP6 适用: 人 FACS 宿主: Human, 兔 Chimeric DMC427 unconjugated Fc fragment Recombinant Antibody
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 339 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- GP6 (Glycoprotein VI (Platelet) (GP6))
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别名
- GP6
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背景
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Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Collagen receptor involved in collagen-induced platelet adhesion and activation. GP6 plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke (Jandrot-Perrus et al., 2000 [PubMed 10961879]).[supplied by OMIM].
Alias Symbols: GPIV, GPVI, MGC138168, BDPLT11
Protein Interaction Partner: NCF1, TRAF4, TGFB1I1, LYN, PTK2B, CALM1, FCER1G, YES1, FCGR2A, FCGR3A, FYN, CRP,
Protein Size: 339 -
分子量
- 37 kDa
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基因ID
- 51206
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NCBI登录号
- NM_016363, NP_057447
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UniProt
- Q9HCN6
抗原
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