RRM1 抗体 (N-Term)
Quick Overview for RRM1 抗体 (N-Term) (ABIN2782439)
抗原
See all RRM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- ATGSYIAGTN GNSNGLVPML RVYNNTARYV DQGGNKRPGA FAIYLEPWHL
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 100%, Zebrafish: 100%
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产品特性
- This is a rabbit polyclonal antibody against RRM1. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Protein A purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human RRM1
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anti-Ribonucleotide Reductase M1 (RRM1) (AA 593-792) antibody
RRM1 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Ribonucleotide Reductase M1 (RRM1) (AA 541-792) antibodyRRM1 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 2D6D8 unconjugated
anti-Ribonucleotide Reductase M1 (RRM1) (AA 1-213) antibodyRRM1 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ribonucleotide Reductase M1 (RRM1) (Center) antibodyRRM1 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ribonucleotide Reductase M1 (RRM1) (AA 593-792) antibodyRRM1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D6 unconjugated
anti-Ribonucleotide Reductase M1 (RRM1) (AA 541-792) antibodyRRM1 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 5G5 unconjugated
anti-Ribonucleotide Reductase M1 (RRM1) (AA 733-778) antibodyRRM1 适用: 人 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Ribonucleotide Reductase M1 (RRM1) antibodyRRM1 适用: 人, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ribonucleotide Reductase M1 (RRM1) (Internal Region) antibodyRRM1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ribonucleotide Reductase M1 (RRM1) antibodyRRM1 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 3D6H5 unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 792 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- RRM1 (Ribonucleotide Reductase M1 (RRM1))
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别名
- RRM1
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背景
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RRM1 is one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. Its gene is located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. Its gene may play a role in malignancies and disease that involve this region.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.This gene encodes one of two non-identical subunits which constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. This gene is oriented in a head-to-tail configuration with the stromal interaction molecule 1 gene (STIM1), with the 3' end of STIM1 situated 1.6 kb from the 5' end of this gene.
Alias Symbols: R1, RIR1, RR1
Protein Interaction Partner: UBC, RRM1, SUMO2, RNF2, BMI1, PPIB, TNPO1, FBXO6, PPP1CC, TMEM177, DNAJB11, SUCLA2, SGSH, NDUFV1, EEF2, DNASE2, COPS5, CDK2, RRM2, RRM2B, KAT5, LRIF1, YWHAG,
Protein Size: 792 -
分子量
- 90 kDa
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基因ID
- 6240
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NCBI登录号
- NM_001033, NP_001024
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UniProt
- P23921
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途径
- Positive Regulation of Endopeptidase Activity
抗原
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