RRM1 抗体 (C-Term)
(3 references)-
- 抗原 See all RRM1 抗体
- RRM1 (Ribonucleotide Reductase M1 (RRM1))
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抗原表位
- C-Term
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适用
- 人, 小鼠, 大鼠, 斑马鱼, 犬, 马, 兔, 豚鼠, Cow
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RRM1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- MHFYGWKQGL KTGMYYLRTR PAANPIQFTL NKEKLKDKEK VSKEEEEKER
- 预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%
- 产品特性
- This is a rabbit polyclonal antibody against RRM1. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Protein A purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the C terminal region of human RRM1
- Top Product
- Discover our top product RRM1 Primary Antibody
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anti-Ribonucleotide Reductase M1 (RRM1) (AA 593-792) antibody
RRM1 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Ribonucleotide Reductase M1 (RRM1) (AA 541-792) antibodyRRM1 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 2D6D8 unconjugated
anti-Ribonucleotide Reductase M1 (RRM1) (AA 1-213) antibodyRRM1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ribonucleotide Reductase M1 (RRM1) (Center) antibodyRRM1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Ribonucleotide Reductase M1 (RRM1) (AA 593-792) antibodyRRM1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D6 unconjugated
anti-Ribonucleotide Reductase M1 (RRM1) (AA 541-792) antibodyRRM1 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 5G5 unconjugated
anti-Ribonucleotide Reductase M1 (RRM1) (AA 733-778) antibodyRRM1 适用: 人 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Ribonucleotide Reductase M1 (RRM1) antibodyRRM1 适用: 人, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ribonucleotide Reductase M1 (RRM1) (Internal Region) antibodyRRM1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ribonucleotide Reductase M1 (RRM1) antibodyRRM1 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 3D6H5 unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 792 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "The effect of the acid-sensitivity of 4-(N)-stearoyl gemcitabine-loaded micelles on drug resistance caused by RRM1 overexpression." in: Biomaterials, Vol. 34, Issue 9, pp. 2327-39, (2013) (PubMed).
: "Stearoyl gemcitabine nanoparticles overcome resistance related to the over-expression of ribonucleotide reductase subunit M1." in: Journal of controlled release : official journal of the Controlled Release Society, Vol. 157, Issue 1, pp. 132-40, (2012) (PubMed).
: "Silencing of ribonucleotide reductase subunit M1 potentiates the antitumor activity of gemcitabine in resistant cancer cells." in: Cancer biology & therapy, Vol. 13, Issue 10, pp. 908-14, (2012) (PubMed).
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: "The effect of the acid-sensitivity of 4-(N)-stearoyl gemcitabine-loaded micelles on drug resistance caused by RRM1 overexpression." in: Biomaterials, Vol. 34, Issue 9, pp. 2327-39, (2013) (PubMed).
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- 抗原
- RRM1 (Ribonucleotide Reductase M1 (RRM1))
- 别名
- RRM1 (RRM1 产品)
- 别名
- CG5371 antibody, DmRNR1 antibody, Dmel\\CG5371 antibody, RNR1 antibody, RnrM1 antibody, RntL antibody, l(2)k06709 antibody, XRRM1 antibody, R1 antibody, RIR1 antibody, RR1 antibody, CHUNP6866 antibody, cb396 antibody, cb838 antibody, r1 antibody, sb:cb548 antibody, wu:fb39b07 antibody, wu:fi14b02 antibody, wu:fk95f07 antibody, ribonucleotide reductase catalytic subunit M1 antibody, Ribonucleoside diphosphate reductase large subunit antibody, ribonucleoside-diphosphate reductase large subunit antibody, ribonucleotide reductase M1 L homeolog antibody, ribonucleotide reductase M1 antibody, ribonucleotide reductase M1 polypeptide antibody, RRM1 antibody, RnrL antibody, LOC100472317 antibody, rrm1 antibody, rrm1.L antibody, Rrm1 antibody
- 背景
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RRM1 is one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. Its gene is located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. Its gene may play a role in malignancies and disease that involve this region.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.This gene encodes one of two non-identical subunits which constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. This gene is oriented in a head-to-tail configuration with the stromal interaction molecule 1 gene (STIM1), with the 3' end of STIM1 situated 1.6 kb from the 5' end of this gene.
Alias Symbols: R1, RIR1, RR1
Protein Interaction Partner: UBC, RRM1, SUMO2, RNF2, BMI1, PPIB, TNPO1, FBXO6, PPP1CC, TMEM177, DNAJB11, SUCLA2, SGSH, NDUFV1, EEF2, DNASE2, COPS5, CDK2, RRM2, RRM2B, KAT5, LRIF1, YWHAG,
Protein Size: 792 - 分子量
- 90 kDa
- 基因ID
- 6240
- NCBI登录号
- NM_001033, NP_001024
- UniProt
- P23921
- 途径
- Positive Regulation of Endopeptidase Activity
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