NCF4 抗体 (N-Term)
Quick Overview for NCF4 抗体 (N-Term) (ABIN2782428)
抗原
See all NCF4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- SKYLIYRRYR QFHALQSKLE ERFGPDSKSS ALACTLPTLP AKVYVGVKQE
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预测反应
- Cow: 85%, Dog: 86%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 92%, Pig: 92%, Rabbit: 85%, Rat: 92%
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产品特性
- This is a rabbit polyclonal antibody against NCF4. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human NCF4
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anti-Neutrophil Cytosolic Factor 4, 40kDa (NCF4) (AA 111-339) antibody
NCF4 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neutrophil Cytosolic Factor 4, 40kDa (NCF4) (Internal Region) antibodyVerified NCF4 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Neutrophil Cytosolic Factor 4, 40kDa (NCF4) antibodyNCF4 适用: 人 WB, IHC, IP 宿主: 兔 Monoclonal unconjugated
anti-Neutrophil Cytosolic Factor 4, 40kDa (NCF4) (C-Term) antibodyNCF4 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Neutrophil Cytosolic Factor 4, 40kDa (NCF4) (AA 1-190) antibodyNCF4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Neutrophil Cytosolic Factor 4, 40kDa (NCF4) (AA 136-239) antibodyNCF4 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Neutrophil Cytosolic Factor 4, 40kDa (NCF4) (AA 1-339) antibodyNCF4 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Neutrophil Cytosolic Factor 4, 40kDa (NCF4) (AA 1-339) antibodyNCF4 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Neutrophil Cytosolic Factor 4, 40kDa (NCF4) (AA 260-289), (C-Term) antibodyNCF4 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB18508 unconjugated
anti-Neutrophil Cytosolic Factor 4, 40kDa (NCF4) antibodyNCF4 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 348 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- NCF4 (Neutrophil Cytosolic Factor 4, 40kDa (NCF4))
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别名
- NCF4
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背景
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NCF4 is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Alias Symbols: MGC3810, NCF, P40PHOX, SH3PXD4
Protein Interaction Partner: NCF2, UBC, CORO1A, MSN, CYBB, NCF1, CYBA, TXN, PRKCD, XRCC6, PRKDC,
Protein Size: 348 -
分子量
- 39 kDa
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基因ID
- 4689
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NCBI登录号
- NM_013416, NP_038202
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UniProt
- A8K4F9
抗原
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