Dysferlin 抗体 (Middle Region)
(1 reference)Quick Overview for Dysferlin 抗体 (Middle Region) (ABIN2782235)
抗原
See all Dysferlin (DYSF) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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序列
- SRILDESEDT DLPYPPPQRE ANIYMVPQNI KPALQRTAIE ILAWGLRNMK
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预测反应
- Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 100%, Zebrafish: 92%
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产品特性
- This is a rabbit polyclonal antibody against DYSF. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human DYSF
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anti-Dysferlin (DYSF) (AA 105-278) antibody
DYSF 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Dysferlin (DYSF) (C-Term) antibodyDYSF 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Dysferlin (DYSF) antibodyDYSF 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Dysferlin (DYSF) (AA 1584-1633) antibodyDYSF 适用: 人, 小鼠, 豚鼠, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Dysferlin (DYSF) (AA 215-264) antibodyDYSF 适用: 人, Cow, 犬, 豚鼠, 兔, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Dysferlin (DYSF) (AA 1999-2016) antibodyDYSF 适用: 人 IHC, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal Ham1-7B6 unconjugated
anti-Dysferlin (DYSF) (AA 1-479) antibodyDYSF 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Dysferlin (DYSF) (C-Term) antibodyDYSF 适用: 人, 小鼠, 大鼠, Cow, 犬, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 2080 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "Dysferlinopathy in the Jews of the Caucasus: a frequent mutation in the dysferlin gene." in: Neuromuscular disorders : NMD, Vol. 17, Issue 11-12, pp. 950-4, (2007) (PubMed).
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: "Dysferlinopathy in the Jews of the Caucasus: a frequent mutation in the dysferlin gene." in: Neuromuscular disorders : NMD, Vol. 17, Issue 11-12, pp. 950-4, (2007) (PubMed).
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- Dysferlin (DYSF)
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别名
- DYSF
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背景
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DYSF belongs to the ferlin family and is a skeletal muscle protein found associated with the sarcolemma. It is involved in muscle contraction and contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. In addition, DYSF binds caveolin-3, a skeletal muscle membrane protein which is important in the formation of caveolae. Specific mutations in this gene have been shown to cause autosomal recessive limb girdle muscular dystrophy type 2B (LGMD2B) as well as Miyoshi myopathy.The protein encoded by this gene belongs to the ferlin family and is a skeletal muscle protein found associated with the sarcolemma. It is involved in muscle contraction and contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. In addition, the protein encoded by this gene binds caveolin-3, a skeletal muscle membrane protein which is important in the formation of caveolae. Specific mutations in this gene have been shown to cause autosomal recessive limb girdle muscular dystrophy type 2B (LGMD2B) as well as Miyoshi myopathy. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FER1L1, FLJ00175, FLJ90168, LGMD2B, MMD1
Protein Interaction Partner: UBC, HECW2, HDAC6, CAV3, ANXA2, ANXA1, CAPN3,
Protein Size: 2080 -
分子量
- 237 kDa
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基因ID
- 8291
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NCBI登录号
- NM_003494, NP_003485
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UniProt
- O75923
抗原
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