SPPL2B antibody, wu:fc16e01 antibody, wu:fc85d12 antibody, zgc:136525 antibody, MGC147524 antibody, IMP-4 antibody, IMP4 antibody, PSH4 antibody, PSL1 antibody, 3110056O03Rik antibody, AW550292 antibody, RGD1308556 antibody, signal peptide peptidase-like 2 antibody, signal peptide peptidase like 2B antibody, signal peptide peptidase like 2B S homeolog antibody, signal peptide peptidase-like 2B antibody, sppl2 antibody, sppl2b antibody, sppl2b.S antibody, SPPL2B antibody, Sppl2b antibody
背景
SPPL2B is a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Alias Symbols: IMP-4, IMP4, PSH4, PSL1 Protein Size: 307