LFNG 抗体 (N-Term)
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北京 101111
Quick Overview for LFNG 抗体 (N-Term) (ABIN2782070)
抗原
See all LFNG 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- LFNG Antibody - N-terminal region
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序列
- LSEYFSLLTR ARRDAGPPPG AAPRPADGHP RPLAEPLAPR DVFIAVKTTK
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预测反应
- Cow: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Yeast: 100%
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产品特性
- This is a rabbit polyclonal antibody against LFNG. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human LFNG
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8104398
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- prevent freeze-thaw cycles
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储存条件
- 4 °C,-20 °C
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储存方法
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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- LFNG (LFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase (LFNG))
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别名
- LFNG
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背景
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Background Information: This gene is a member of the glycosyltransferase 31 gene family. Members of this gene family, which also includes the MFNG (GeneID: 4242) and RFNG (GeneID: 5986) genes, encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, these proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. The protein encoded by this gene is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3.
Gene Name: LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Alternative Symbols: SCDO3
Protein Name: beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
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分子量
- 39kDa
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基因ID
- 3955
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NCBI登录号
- NP_001035258
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UniProt
- Q8NES3
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途径
- Notch Signaling
抗原
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