UBR1 抗体 (N-Term)
(1 reference)Quick Overview for UBR1 抗体 (N-Term) (ABIN2781277)
抗原
See all UBR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- YKQLQKEYIS DDHDRSISIT ALSVQMFTVP TLARHLIEEQ NVISVITETL
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预测反应
- Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Yeast: 82%
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产品特性
- This is a rabbit polyclonal antibody against UBR1. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human UBR1
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anti-Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) (AA 2-100) antibody
UBR1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2F5 unconjugated
anti-Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) (AA 722-862) antibodyUBR1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) (AA 2-100) antibodyUBR1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) (AA 2-100) antibodyUBR1 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 4G7 unconjugated
anti-Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) (AA 801-900) antibodyUBR1 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) (Internal Region) antibodyUBR1 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) (AA 396-445) antibodyUBR1 适用: 人, 犬, 兔, 猴, 豚鼠, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) (N-Term) antibodyUBR1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) (AA 245-274), (N-Term) antibodyUBR1 适用: 小鼠 WB 宿主: 兔 Polyclonal RB41861 unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 1749 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "Lack of association of genetic variation in chromosome region 15q14-22.1 with type 2 diabetes in a Japanese population." in: BMC medical genetics, Vol. 9, pp. 22, (2008) (PubMed).
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: "Lack of association of genetic variation in chromosome region 15q14-22.1 with type 2 diabetes in a Japanese population." in: BMC medical genetics, Vol. 9, pp. 22, (2008) (PubMed).
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- UBR1 (Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1))
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别名
- UBR1
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背景
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UBR1 is an E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. UBR1 may be involved in pancreatic homeostasis.The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: JBS, MGC142065, MGC142067
Protein Interaction Partner: CDC6, UBC, SHFM1, UBE2D1, CBX8, ZNF593, DNPH1, USP5, XPO1, PFAS, CSE1L, ATP6V1A, VCL, UCHL3, CUL2, RECQL4, TIRAP, DNAJB11, NUDT3, SPRY2, LAMTOR3, UBE2A, GSK3B, GADD45A, BCL2L1, UBE2Z, NSFL1C, UBXN1, UBXN7, FAF2, FAF1, FOS, HNRNPA1, NDUFA4L2, ARL15, BTBD2,
Protein Size: 1749 -
分子量
- 200 kDa
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基因ID
- 197131
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NCBI登录号
- NM_174916, NP_777576
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UniProt
- Q8IWV7
抗原
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