SETDB1 抗体 (N-Term)
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北京 101111
Quick Overview for SETDB1 抗体 (N-Term) (ABIN2780883)
抗原
See all SETDB1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- PGCIGLDAAT ATVESEEIAE LQQAVVEELG ISMEELRHFI DEELEKMDCV
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预测反应
- Cow: 92%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Rabbit: 85%, Rat: 86%
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产品特性
- This is a rabbit polyclonal antibody against SETDB1. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N-terminal region of Human SETDB1
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anti-SET Domain, Bifurcated 1 (SETDB1) (AA 2-100) antibody
SETDB1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4A3 unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) (AA 1-397) antibodySETDB1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) antibodySETDB1 适用: 人, 小鼠, 猴 WB, ELISA, ICC 宿主: 小鼠 Monoclonal 5H6A12 unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) (AA 1-397) antibodySETDB1 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) antibodySETDB1 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) (AA 1193-1225) antibodySETDB1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) (AA 2-100) antibodySETDB1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) (AA 1193-1225), (C-Term) antibodySETDB1 适用: 人 WB 宿主: 兔 Polyclonal RB5748 unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) (AA 1050-1075) antibodySETDB1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeat freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- SETDB1 (SET Domain, Bifurcated 1 (SETDB1))
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别名
- SETDB1
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背景
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SETDB1 is a histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. SETDB1 mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. It probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins.
Protein Interaction Partner: MDM2, HSP90AA1, UBC, SKIL, LRIF1, BARD1, APLP1, TCERG1, TRIM28, VIM, SUMO2, PML, CLSTN1, JARID2, tat, MZT2B, FAM118B, MRPL44, LUC7L2, MAP4K5, TSC22D1, TTR, TK1, SMN1, PCYT2, PSME1, GRB7, CDKN1A, CDK4, BID, ANXA7, ZNF274, HIST1H3A, ESCO1, AKT2, AKT1, PPARG
Protein Size: 397 -
分子量
- 43 kDa
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基因ID
- 9869
抗原
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