FGD1 抗体 (N-Term)
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北京 101111
Quick Overview for FGD1 抗体 (N-Term) (ABIN2780596)
抗原
See all FGD1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- HGHRAPGGAG PSEPEHPATN PPGAAPPACA DSDPGASEPG LLARRGSGSA
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预测反应
- Cow: 86%, Human: 100%, Pig: 86%, Rat: 79%
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产品特性
- This is a rabbit polyclonal antibody against FGD1. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human FGD1
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anti-FYVE, RhoGEF and PH Domain Containing 1 (FGD1) (AA 700-800) antibody
FGD1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-FYVE, RhoGEF and PH Domain Containing 1 (FGD1) (C-Term) antibodyFGD1 适用: 人, Cow, 犬, Pig, 大鼠, 小鼠, 兔, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-FYVE, RhoGEF and PH Domain Containing 1 (FGD1) (C-Term) antibodyFGD1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-FYVE, RhoGEF and PH Domain Containing 1 (FGD1) (N-Term) antibodyFGD1 适用: 人, Cow, 犬, Pig, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-FYVE, RhoGEF and PH Domain Containing 1 (FGD1) (N-Term) antibodyFGD1 适用: 人, Cow, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-FYVE, RhoGEF and PH Domain Containing 1 (FGD1) (C-Term) antibodyFGD1 适用: 人, Cow, 犬, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-FYVE, RhoGEF and PH Domain Containing 1 (FGD1) antibodyFGD1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 961 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice." in: The Journal of clinical investigation, Vol. 121, Issue 11, pp. 4383-92, (2011) (PubMed).
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: "MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice." in: The Journal of clinical investigation, Vol. 121, Issue 11, pp. 4383-92, (2011) (PubMed).
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- FGD1 (FYVE, RhoGEF and PH Domain Containing 1 (FGD1))
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别名
- FGD1
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背景
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FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome.FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: AAS, FGDY, ZFYVE3, MRXS16
Protein Interaction Partner: BTRC, UBC, ELAVL1, ELMO1, CTTN, CDC42, AOC1,
Protein Size: 961 -
分子量
- 106 kDa
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基因ID
- 2245
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NCBI登录号
- NM_004463, NP_004454
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UniProt
- P98174
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途径
- Neurotrophin Signaling Pathway
抗原
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