NMRAL1 抗体 (N-Term)
Quick Overview for NMRAL1 抗体 (N-Term) (ABIN2780056)
抗原
See all NMRAL1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- GATGAQGGSV ARALLEDGTF RIRVVTRNPE QRAAKELKQQ GAEVVRGDQD
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预测反应
- Cow: 79%, Dog: 79%, Mouse: 100%, Pig: 86%, Rat: 86%
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产品特性
- This is a rabbit polyclonal antibody against Nmral1. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the n terminal region of mouse Nmral1
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anti-NmrA-Like Family Domain Containing 1 (NMRAL1) (AA 1-299) antibody
NMRAL1 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-NmrA-Like Family Domain Containing 1 (NMRAL1) (AA 1-299) antibodyNMRAL1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-NmrA-Like Family Domain Containing 1 (NMRAL1) (AA 216-265) antibodyNMRAL1 适用: 人, 大鼠, Cow, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-NmrA-Like Family Domain Containing 1 (NMRAL1) (Middle Region) antibodyNMRAL1 适用: 人, 大鼠, 小鼠, Cow, 犬, 豚鼠, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 309 AA
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- NMRAL1 (NmrA-Like Family Domain Containing 1 (NMRAL1))
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别名
- Nmral1
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背景
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Nmral1 is a redox sensor protein. Nmral1 undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP+ levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH.Nmral1 has higher affinity for NADPH than for NADP+. Binding to NADPH is necessary to form a stable dimer.
Alias Symbols: 1110025F24Rik, AI256624
Protein Size: 309 -
分子量
- 34 kDa
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基因ID
- 67824
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NCBI登录号
- NM_026393, NP_080669
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UniProt
- Q8K2T1
抗原
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