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PTK2B 抗体 (C-Term)

PTK2B 适用: 人, 小鼠, 大鼠, 犬, 兔, Pig, 马, 豚鼠, Cow WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2779801
发货至: 中国
  • 抗原 See all PTK2B 抗体
    PTK2B (PTK2B Protein tyrosine Kinase 2 beta (PTK2B))
    抗原表位
    • 24
    • 21
    • 17
    • 15
    • 10
    • 7
    • 6
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
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    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    • 114
    • 113
    • 95
    • 7
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, 犬, 兔, Pig, 马, 豚鼠, Cow
    宿主
    • 145
    • 13
    • 3
    克隆类型
    • 140
    • 21
    多克隆
    标记
    • 75
    • 11
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    This PTK2B antibody is un-conjugated
    应用范围
    • 123
    • 59
    • 44
    • 40
    • 39
    • 26
    • 13
    • 13
    • 9
    • 4
    • 1
    • 1
    Western Blotting (WB)
    序列
    KSPLTPEKEV GYLEFTGPPQ KPPRLGAQSI QPTANLDRTD DLVYLNVMEL
    预测反应
    Cow: 93%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%
    产品特性
    This is a rabbit polyclonal antibody against PTK2B. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the C terminal region of human PTK2B
    Top Product
    Discover our top product PTK2B Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 1009 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Ling, Sheng, Braun: "The calcium-dependent activity of large-conductance, calcium-activated K+ channels is enhanced by Pyk2- and Hck-induced tyrosine phosphorylation." in: American journal of physiology. Cell physiology, Vol. 287, Issue 3, pp. C698-706, (2004) (PubMed).

  • 抗原
    PTK2B (PTK2B Protein tyrosine Kinase 2 beta (PTK2B))
    别名
    PTK2B (PTK2B 产品)
    别名
    CADTK antibody, CAKB antibody, FADK2 antibody, FAK2 antibody, PKB antibody, PTK antibody, PYK2 antibody, RAFTK antibody, CAKbeta antibody, E430023O05Rik antibody, Raftk antibody, Pyk2 antibody, fak1b antibody, ptk2.2 antibody, ptk2b antibody, si:ch1073-355e8.1 antibody, protein tyrosine kinase 2 beta antibody, PTK2 protein tyrosine kinase 2 beta antibody, protein tyrosine kinase 2aa antibody, PTK2B antibody, Ptk2b antibody, ptk2aa antibody
    背景
    PTK2B encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies.
    Alias Symbols: PKB, PTK, CAKB, FAK2, PYK2, CADTK, FADK2, RAFTK
    Protein Interaction Partner: CBLB, UBC, EGFR, PXN, HSP90AA1, MAPT, GP6, TRAF4, BCAR1, SKAP2, GP1BB, UL49, SOCS3, SRC, GRB2, FYN, DNM1, ALG2, SH3KBP1, PDCD6IP, CBL, SOCS2, PTEN, MBD2, DLGAP3, STAP1, SORBS2, NEDD9, EFS, NPHP1, PITPNM2, PITPNM3, PITPNM1, ARHGAP21, RB1CC1, ASAP1, LPXN, P
    Protein Size: 1009
    分子量
    116 kDa
    基因ID
    2185
    NCBI登录号
    NM_004103, NP_004094
    UniProt
    Q14289
    途径
    EGFR Signaling Pathway, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Cellular Glucan Metabolic Process, Cell-Cell Junction Organization, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Positive Regulation of fat Cell Differentiation, VEGF Signaling
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